120824-90-0Relevant academic research and scientific papers
Process and intermediates for the preparation of halogenated protease inhibitors
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, (2008/06/13)
This invention relates to novel intermediate compounds which are useful for producing the halogenated protease inhibitors that are the subject matter of U.S. Pat. No. 4,469,885. In particular, the invention relates to novel methods and intermediates for making said protease inhibitors, the intermediate compounds being of the formula: STR1 wherein R1 is: (a) straight or branched chain lower alkyl having 1-6 carbon atoms; or (b) H; wherein R6 is: (a) straight or branched chain higher alkyl having 13-25 carbon atoms; or (b) straight or branched chain higher alkenyl having 13-25 carbon atoms; wherein R5 is: (a) straight or branched chain lower alkyl having 1-6 carbon atoms; or (b) benzyl; wherein R7 is: (a) straight or branched chain lower alkyl having 1-6 carbon atoms; or (b) H; wherein R2 is: (a) --Cl, --Br, or --I; or (b) --CF3.
