1208255-45-1Relevant articles and documents
Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis
Hwang, Jong Yeon,Smithson, David,Connelly, Michele,Maier, Julie,Zhu, Fangyi,Guy, Kiplin R.
supporting information; experimental part, p. 149 - 152 (2010/04/29)
A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.