1208258-44-9Relevant academic research and scientific papers
Cyclopentadienyltin(IV) derivatives: Synthesis, characterization and study of their cytotoxic activities
Gómez-Ruiz, Santiago,Prashar, Sanjiv,Walther, Till,Fajardo, Mariano,Steinborn, Dirk,Paschke, Reinhard,Kaluderovi?, Goran N.
, p. 16 - 23 (2010/03/30)
The organotin compounds, [SnPh3(C5H4R)] (R = But (1), CMe2(CH2CH2CH{double bond, long}CH2) (2)) and [SnPh3(C5Me4R)] (R = H (3), SiMe3 (4)), were prepared by the reaction of SnPh3Cl with the lithium derivative of the corresponding cyclopentadiene. 1-4 have been characterized by multinuclear NMR spectroscopy (1H, 13C{1H} and 119Sn{1H}). In addition, the molecular structures of 1, 2 and 4 were determined by single-crystal X-ray diffraction studies. The cytotoxic activity of the organotin(IV) complexes (1-4) was tested against human tumour cell lines 8505C anaplastic thyroid cancer, A253 head and neck tumour, A549 lung carcinoma, A2780 ovarian cancer, DLD-1 colon carcinoma. Compounds 1-4 present higher activities than cisplatin in all the studied cells. The highest sensitivity of the synthesized tin(IV) complexes was observed against A2780 ovarian cancer and DLD-1 colon carcinoma. Complex 3 presents the highest cytotoxic activity of all the studied complexes in all the cancer cells, with IC50 values from 0.037 to 0.085 μM, however, its trimethylsilyl-substituted analogue (4), showed the lowest activity against all the studied cells with IC50 values from 0.163 to 0.351 μM. Complexes 1 and 2 presented very similar activities on all the cancer cells (IC50 values from 0.044 to 0.119 μM).
