12083-48-6 Usage
Chemical Properties
dark green crystalline powder
Uses
Different sources of media describe the Uses of 12083-48-6 differently. You can refer to the following data:
1. Vanadocene dichloride is used like other metallocenes as a
catalyst, ultraviolet absorber, reducing agent, free radical
scavenger, antiknock agent in gasoline, and as a developmental
anticancer drug.
2. Bis(cyclopentadienyl)vanadium(IV) dichloride is a catalyst for solvent free, room temperature preparation of vicinal amino alcohols as fungistatic agents, catalyst fot oligomerization reactions via the Aufbau propagation reaction and as a catalyst for aqueous polymerization reactions using oxygen as a co catalyst. It is used as a catalyst for dl-selective pinacol-type coupling reactions, as an affecter of crystal growth of calcium carbonate and and as an inhibitor of human topoisomerase II enzyme with antitumor activity.
General Description
Pale green crystals or green powder.
Air & Water Reactions
Extremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water
Reactivity Profile
Organometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.
Fire Hazard
Flash point data for BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible.
Pharmaceutical Applications
Different sources of media describe the Pharmaceutical Applications of 12083-48-6 differently. You can refer to the following data:
1. Vanadocene dichloride [( η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic . Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis.
2. Vanadocene dichloride [(η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic. Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing.
Check Digit Verification of cas no
The CAS Registry Mumber 12083-48-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,0,8 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 12083-48:
(7*1)+(6*2)+(5*0)+(4*8)+(3*3)+(2*4)+(1*8)=76
76 % 10 = 6
So 12083-48-6 is a valid CAS Registry Number.
InChI:InChI=1/2C5H5.2ClH.V/c2*1-2-4-5-3-1;;;/h2*1-5H;2*1H;/q2*-1;;;+2/p-2
12083-48-6Relevant articles and documents
Jimenez-Tenorio, M.,Leigh, G. J.
, p. 1784 - 1785 (1989)
Razuvaev, G. A.,Bayushkin, P. Ya.,Cherkasov, V. K.,Gladyshev, E. N.,Phokeev, A. P.
, p. L103 - L104 (1980)
Vanadacyclopropene Phosphane Cp2V(η2-PhC=C)P(C=CPh)Ar
Choukroun, Robert,Miquel, Yannick,Donnadieu, Bruno,Igau, Alain,Blandy, Claudine,Majoral, Jean Pierre
, p. 1795 - 1797 (1999)
Treatment of the bis(alkynyl)phosphane Ar-P(C=CPh)2 (3) (Ar = 2,4,6-t-Bu3C6H2) with Cp2V gives the vanadacyclopropene phosphane 5, which was characterized by X-ray diffraction. The reactivity of 5 tow
New 1,1′-ring-substituted vanadocene bichlorides. Crystal structures of [V(η5-C5H4SiMe3) 2Cl2] and [V(η5-C5H5)2Cl2]
Tzavellas,Klouras,Raptopoulou
, p. 898 - 902 (1996)
The 1,1′-ring-substituted vanadocene dichlorides [V(η5-C5H4R)2Cl2] (R = CMe3, SiMe3, SiEt3) have been prepared from VCl4 and the appropriate lithiated cyclopentadiene, C5H4RLi, in 1:2 ratios. All complexes were characterized by elemental microanalysis and IR spectroscopy. The crystal structures of [V(η5-C5H4SiMe3) 2Cl2] 3 and the parent compound [V(η5-C5H5)2Cl2] 1 have been determined by X-ray diffraction and are in accordance with expectations. Compound 1 crystallizes with two crystallographically independent molecules in its monoclinic unit cell. These two molecules are quite similar in their essential structural features. Compound 3 crystallizes in the triclinic space group P1. The trimethylsilylcyclopentadienyl rings are bound in a staggered relative orientation. Johann Ambrosius Barth 1996.
Reactions of vanadocene and its monochloride with p-toluenesulfonyl chloride
Gordetsov,Latyaeva,Zimina,Levakova,Cherkasov,Moseeva,Skobeleva
, p. 1214 - 1217 (2007/10/03)
The reactions of Cp2V and Cp2VCI with p-toluenesulfonyl chloride were studied. Depending on the ratio of the reagents, the solvent, and other reaction conditions, the compounds p-MeC6H4SO2VCp2/s
