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12083-48-6

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12083-48-6 Usage

Description

BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, also known as vanadocene dichloride, is a chemical compound with the formula (C5H5)2VCl2. It is a pale green crystalline powder that exhibits a variety of chemical properties and applications across different industries.

Uses

Used in Chemical Industry:
BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is used as a catalyst for various chemical reactions, including solvent-free, room temperature preparation of vicinal amino alcohols as fungistatic agents, oligomerization reactions via the Aufbau propagation reaction, and aqueous polymerization reactions using oxygen as a co-catalyst.
Used in Automotive Industry:
BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is used as an antiknock agent in gasoline, improving the performance and efficiency of internal combustion engines.
Used in Pharmaceutical Industry:
BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is used as a developmental anticancer drug, exhibiting antitumor activity by inhibiting human topoisomerase II enzyme.
Used in Material Science:
BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is used as an affecter of crystal growth of calcium carbonate, which can have applications in the development of new materials and coatings.
Used in Environmental Protection:
BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is used as a reducing agent, free radical scavenger, and ultraviolet absorber, which can help protect the environment by reducing harmful effects of pollutants and UV radiation.

Air & Water Reactions

Extremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water

Reactivity Profile

Organometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.

Fire Hazard

Flash point data for BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible.

Pharmaceutical Applications

Vanadocene dichloride [( η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic . Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis.

Pharmaceutical Applications

Vanadocene dichloride [(η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic. Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing.

Check Digit Verification of cas no

The CAS Registry Mumber 12083-48-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,0,8 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 12083-48:
(7*1)+(6*2)+(5*0)+(4*8)+(3*3)+(2*4)+(1*8)=76
76 % 10 = 6
So 12083-48-6 is a valid CAS Registry Number.
InChI:InChI=1/2C5H5.2ClH.V/c2*1-2-4-5-3-1;;;/h2*1-5H;2*1H;/q2*-1;;;+2/p-2

12083-48-6 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • TCI America

  • (V0090)  Vanadinocene Dichloride  >98.0%(T)

  • 12083-48-6

  • 1g

  • 890.00CNY

  • Detail
  • Alfa Aesar

  • (39588)  Bis(cyclopentadienyl)vanadium dichloride, 95%   

  • 12083-48-6

  • 1g

  • 1126.0CNY

  • Detail
  • Alfa Aesar

  • (39588)  Bis(cyclopentadienyl)vanadium dichloride, 95%   

  • 12083-48-6

  • 5g

  • 2820.0CNY

  • Detail
  • Aldrich

  • (334642)  Bis(cyclopentadienyl)vanadium(IV)dichloride  95%

  • 12083-48-6

  • 334642-1G

  • 706.68CNY

  • Detail

12083-48-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Vanadinocene Dichloride

1.2 Other means of identification

Product number -
Other names BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:12083-48-6 SDS

12083-48-6Relevant articles and documents

Jimenez-Tenorio, M.,Leigh, G. J.

, p. 1784 - 1785 (1989)

Razuvaev, G. A.,Bayushkin, P. Ya.,Cherkasov, V. K.,Gladyshev, E. N.,Phokeev, A. P.

, p. L103 - L104 (1980)

Vanadacyclopropene Phosphane Cp2V(η2-PhC=C)P(C=CPh)Ar

Choukroun, Robert,Miquel, Yannick,Donnadieu, Bruno,Igau, Alain,Blandy, Claudine,Majoral, Jean Pierre

, p. 1795 - 1797 (1999)

Treatment of the bis(alkynyl)phosphane Ar-P(C=CPh)2 (3) (Ar = 2,4,6-t-Bu3C6H2) with Cp2V gives the vanadacyclopropene phosphane 5, which was characterized by X-ray diffraction. The reactivity of 5 tow

New 1,1′-ring-substituted vanadocene bichlorides. Crystal structures of [V(η5-C5H4SiMe3) 2Cl2] and [V(η5-C5H5)2Cl2]

Tzavellas,Klouras,Raptopoulou

, p. 898 - 902 (1996)

The 1,1′-ring-substituted vanadocene dichlorides [V(η5-C5H4R)2Cl2] (R = CMe3, SiMe3, SiEt3) have been prepared from VCl4 and the appropriate lithiated cyclopentadiene, C5H4RLi, in 1:2 ratios. All complexes were characterized by elemental microanalysis and IR spectroscopy. The crystal structures of [V(η5-C5H4SiMe3) 2Cl2] 3 and the parent compound [V(η5-C5H5)2Cl2] 1 have been determined by X-ray diffraction and are in accordance with expectations. Compound 1 crystallizes with two crystallographically independent molecules in its monoclinic unit cell. These two molecules are quite similar in their essential structural features. Compound 3 crystallizes in the triclinic space group P1. The trimethylsilylcyclopentadienyl rings are bound in a staggered relative orientation. Johann Ambrosius Barth 1996.

Reactions of vanadocene and its monochloride with p-toluenesulfonyl chloride

Gordetsov,Latyaeva,Zimina,Levakova,Cherkasov,Moseeva,Skobeleva

, p. 1214 - 1217 (2007/10/03)

The reactions of Cp2V and Cp2VCI with p-toluenesulfonyl chloride were studied. Depending on the ratio of the reagents, the solvent, and other reaction conditions, the compounds p-MeC6H4SO2VCp2/s

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