1208307-63-4Relevant academic research and scientific papers
A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors
Wang, Tiansheng,Ledeboer, Mark W.,Duffy, John P.,Pierce, Albert C.,Zuccola, Harmon J.,Block, Eric,Shlyakter, Dina,Hogan, James K.,Bennani, Youssef L.
scheme or table, p. 153 - 156 (2010/04/02)
Pictet-Spengler condensation of aldehydes or alpha-keto-esters with 4-(2-anilinophenyl)-7-azaindole (11) or deazapurine (12) gave high yields of the 3,4-fused cyclic compounds. SAR studies, by varying the substituted benzaldehyde components, lead to the discovery of a series of potent JAK2 kinase inhibitors.
