1208307-82-7Relevant academic research and scientific papers
Anti-tumor activity of a new series of benzoxazepine derivatives in breast cancer
Samanta, Krishnananda,Chakravarti, Bandana,Mishra, Jitendra Kumar,Dwivedi, Shailendra Kumar Dhar,Nayak, Lakshma Vadithe,Choudhry, Preeti,Bid, Hemant Kumar,Konwar, Rituraj,Chattopadhyay, Naibedya,Panda, Gautam
supporting information; experimental part, p. 283 - 287 (2010/04/06)
A series of new benzoxazepine derivatives substituted with different alkoxy and aryloxy group were synthesized comprising synthetic steps of Mitsunobu reaction, lithium aluminum hydride (LAH) reduction, followed by debenzylation and finally intramolecular Mitsunobu cyclization. The new benzoxazepines specifically inhibited growth of breast cancer cell lines, MCF-7 and MDA-MB-231, but lack cytotoxicity to normal HEK-293 cells. The cell growth inhibition induced by the active compounds was due to cell cycle arrest at G0/G1 phase. The active compound could cause significant reduction in tumor volume of MCF-7 xenograft tumor in nude mice model and their activity was comparable to that of tamoxifen citrate at 16 mg kg-1 dose at 30 days of treatment. The identified most active compounds of the series have specific advantages as anti-cancer agent in breast cancer than tamoxifen.
