1208319-26-9 Usage
Uses
Oclacitinib is a novel Janus kinase (JAK) inhibitor with activity against cytokines involved in allergy.
Biological Activity
janus kinase (jak) enzymes are involved in cell signaling pathways activated by cytokines dysregulated in allergy. pf-03394197 (oclacitinib) is a novel janus kinase inhibitor.
in vitro
pf-03394197 inhibited jak family members by 50% at concentrations ranging from 10 to 99 nm and did not inhibit a panel of 38 non-jak kinases. pf-03394197 was most potent at inhibiting jak1. pf-03394197 also inhibited the function of jak1-dependent cytokines involved in allergy and inflammation as well as pruritus. pf-03394197 had minimal effects on cytokines which did not activate the jak1 enzyme in cells [1].
in vivo
pf-03394197 administered orally at a dose of 0.4–0.6 mg/kg twice daily was safe and efficacious in controlling the pruritus associated with allergic dermatitis. pf-03394197 provided itch relief within 24 h that persisted through the treatment period, with over 70% of the treated dogs achieving a >50% reduction in pruritus by day 7 [2].
IC 50
10 nm for jak1
Check Digit Verification of cas no
The CAS Registry Mumber 1208319-26-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,3,1 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1208319-26:
(9*1)+(8*2)+(7*0)+(6*8)+(5*3)+(4*1)+(3*9)+(2*2)+(1*6)=129
129 % 10 = 9
So 1208319-26-9 is a valid CAS Registry Number.
