1208320-93-7 Usage
General Description
"3H-Pyrazol-3-one, 4-bromo-1,2-dihydro-1,2-dimethyl-5-(6-quinoxalinyl)-" is a chemical compound with a complex molecular structure. It contains a pyrazolone ring with a bromine substitution at the 4 position, as well as two methyl groups at the 1 and 2 positions. In addition, it features a quinoxaline ring attached to the 5 position of the pyrazolone ring. 3H-Pyrazol-3-one, 4-broMo-1,2-dihydro-1,2-diMethyl-5-(6-quinoxalinyl)- has potential applications in pharmaceutical and research settings, and its unique structure may contribute to its various biological activities and properties. Further study and analysis may reveal its potential uses and significance in different fields.
Check Digit Verification of cas no
The CAS Registry Mumber 1208320-93-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,3,2 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1208320-93:
(9*1)+(8*2)+(7*0)+(6*8)+(5*3)+(4*2)+(3*0)+(2*9)+(1*3)=117
117 % 10 = 7
So 1208320-93-7 is a valid CAS Registry Number.
InChI:InChI=1S/C13H11BrN4O/c1-17-12(11(14)13(19)18(17)2)8-3-4-9-10(7-8)16-6-5-15-9/h3-7H,1-2H3
1208320-93-7Relevant articles and documents
Pyrazolone based TGFβR1 kinase inhibitors
Guckian, Kevin,Carter, Mary Beth,Lin, Edward Yin-Shiang,Choi, Michael,Sun, Lihong,Boriack-Sjodin, P. Ann,Chuaqui, Claudio,Lane, Benjamin,Cheung, Kam,Ling, Leona,Lee, Wen-Cherng
, p. 326 - 329 (2010)
Interruption of TGFβ signaling through inhibition of the TGFβR1 kinase domain may prove to have beneficial effect in both fibrotic and oncological diseases. Herein we describe the SAR of a novel series of TGFβR1 kinase inhibitors containing a pyrazolone core. Most TGFβR1 kinase inhibitors described to date contain a core five-membered ring bearing N as H-bond acceptor. Described herein is a novel strategy to replace the core structure with pyrazolone ring, in which the carbonyl group is designed as an H-bond acceptor to interact with catalytic Lys 232.
