1208320-93-7 Usage
Uses
Used in Pharmaceutical Industry:
3H-Pyrazol-3-one, 4-bromo-1,2-dihydro-1,2-dimethyl-5-(6-quinoxalinyl)is used as a potential pharmaceutical agent for its unique structure and biological activities. Its specific application reason is not provided in the materials, but its potential uses may be related to its ability to interact with biological targets or modulate certain pathways.
Used in Research Settings:
3H-Pyrazol-3-one, 4-bromo-1,2-dihydro-1,2-dimethyl-5-(6-quinoxalinyl)is used as a research compound to study its various biological activities and properties. Further analysis and study may reveal its potential uses and significance in different fields, contributing to the advancement of scientific knowledge and the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1208320-93-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,3,2 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1208320-93:
(9*1)+(8*2)+(7*0)+(6*8)+(5*3)+(4*2)+(3*0)+(2*9)+(1*3)=117
117 % 10 = 7
So 1208320-93-7 is a valid CAS Registry Number.
InChI:InChI=1S/C13H11BrN4O/c1-17-12(11(14)13(19)18(17)2)8-3-4-9-10(7-8)16-6-5-15-9/h3-7H,1-2H3
1208320-93-7Relevant academic research and scientific papers
Guckian, Kevin,Carter, Mary Beth,Lin, Edward Yin-Shiang,Choi, Michael,Sun, Lihong,Boriack-Sjodin, P. Ann,Chuaqui, Claudio,Lane, Benjamin,Cheung, Kam,Ling, Leona,Lee, Wen-Cherng
, p. 326 - 329 (2010)
Interruption of TGFβ signaling through inhibition of the TGFβR1 kinase domain may prove to have beneficial effect in both fibrotic and oncological diseases. Herein we describe the SAR of a novel series of TGFβR1 kinase inhibitors containing a pyrazolone core. Most TGFβR1 kinase inhibitors described to date contain a core five-membered ring bearing N as H-bond acceptor. Described herein is a novel strategy to replace the core structure with pyrazolone ring, in which the carbonyl group is designed as an H-bond acceptor to interact with catalytic Lys 232.
