1208337-40-9Relevant academic research and scientific papers
Catalytic double stereoinduction in asymmetric allylic alkylation of oxindoles
Trost, Barry M.,Zhang, Yong
supporting information; experimental part, p. 296 - 303 (2010/03/24)
A highly regio-, diastereo-, and enantioselective allylic alkylation reaction of 3-monosubstituted oxindoles catalyzed by molybdenum is described. The reaction is affected by the electronic and steric variations of the nucleophile. The use of appropriate N-protecting group is particularly important for achieving high regio- and diastereoselectivity. Products from this reaction, containing vicinal quaternary-tertiary stereogenic centers, are valuable synthetic intermediates and should find utility in alkaloid synthesis.
