1208356-08-4

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 6651-50-9 2-methyl-1-trimethyllsilyloxypenta-1,3-diene 
• 86459-87-2 ethyl(E,E)-7-(4'-dimethylaminophenyl)-7-methoxy-4,6-dimethylhepta-1,3-dienoate 
• 623-36-9 (E)-2-methylpent-2-enal 
• 86459-86-1 (E)-5-(4'dimethylaminophenyl)-5-methoxy-2,4-dimethylpent-2-enal 
• 86459-98-5 ethyl 6-bromo-4-methylhepta-2,4-dienoate 
• 86459-85-0 4-(N,N-dimethylamino)benzaldehyde dimethyl acetal 
• 55504-32-0 2-(4-(dimethylamino)phenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 86459-88-3 ethyl(E,E)-6-(4'-dimethylaminobenzoyl)-4-methyl-2,4-heptadienoate 

Relevant academic research and scientific papers

Concise, convergent syntheses of (±)-trichostatin a utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction

Two concise, convergent syntheses of (±)-trichostatin A (1), a potent histone deacetylase inhibitor, have been accomplished. The key step in both is a Pd-catalyzed α-alkenylation reaction between ketone 2 and either dienyl bromide 3 or alkenyl bromide 9 u

An efficient synthesis of (±)-trichostatic acid and analogues: A new route to (±)-trichostatin A

An efficient synthesis of rac-trichostatic acid (1) and Its analogues is reported starting from a commercially available aldehyde. Further manipulations of rac-1 led to rac-trichostatin A (TSA). Construction of the desired molecular architecture entails a two-component union, achieved through an in situ hydroboration followed by a Suzuki-Miyaura coupling with 2. The requisite homopropargyl alcohol was synthesized by exploiting allenylindium chemistry. This new protocol paved the way for the synthesis of analogues of trichostatic acid and hence TSA.