1208368-06-2Relevant articles and documents
Deoxidized halofuginone compound and preparation method and application thereof
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Paragraph 0037; 0038, (2019/01/23)
The invention provides a deoxidized halofuginone compound. A structural formula of the deoxidized halofuginone compound is as shown in the specification, wherein R1 refers to a halogen radical or hydrogen; R2 refers to hydrogen, a halogen radical, C1-C3 alkyl, C1-C3 alkoxy or trifluoromethyl; R3 refers to hydrogen, a halogen radical, C1-C3 alkyl, C1-C3 alkoxy or trifluoromethyl; X1 or X2 refers tonitrogen or carbon; Y refers to hydrogen, hydroxyl or carbonyl. The synthetic deoxidized halofuginone compound with piperidine as a raw material has advantages of cheapness and easiness in acquisition of the raw material, simplicity and easiness in operation of a synthesis method, high yield and product stability. The deoxidized halofuginone compound has great inhibiting effects on Gram positive(Gram) and Gram negative (Gram) and has a promising application prospect in treatment of human and poultry bacterial infection.
NOVEL ADENINE DERIVATIVES
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Page/Page column 63-64, (2010/04/03)
Compounds of formula (I) wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure (II): n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the -(CH2)n- moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
