120848-74-0

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 121183-39-9 2-{[1-(3-Methylbenzoyl)-4-piperidyl]methyl}-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole 
• 128185-61-5 2-[{1-[(3-Methylphenyl)carbonyl]-4-piperidyl}methyl]-2,3-dihydro-1H-isoindole hydrochloride 

Relevant academic research and scientific papers

2,3-DIHYDRO-1H-ISOINDOLE DERIVATIVES AND THEIR APPLICATION IN THERAPY

A benzazepine derivative which is a compound of formula (I): STR1 in which each of m and n denotes the number 1, oreach of m and n denotes the number 2, orm denotes the number 3 and n denotes the number 1; and R denotes hydrogen or a group of formula--Z--R' in which Z denotes a--CO--or--CH 2--group and R' denotes a phenyl group which is unsubtituted or substituted with from one to three substituents selected from halogen atoms, linear or branch (C. sub.1-C 3) alkyl groups and linear or branched (C 1-C 3) alkoxy groups, or a pharmacologically acceptable acid addition salt.

DERIVATIVES OF 2-((4-PIPERIDINYL)METHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

A compound of formula (I): STR1 in which: X is hydrogen or a methyl or methoxy group;Y is a halogen or a methyl or methoxy group; andR is a group of formula--Z--R' in which:Z is a--CH 2--group, and R' is a phenyl group unsubstituted or substituted by one, two or three substituents selected from halogen atoms and trifluoromethyl, linear or branched (C. sub.1-C 3) alkyl and linear or branched (C 1-C 3) alkoxy groups;or a pharmacologically acceptable acid addition salt thereof.

2-((4-piperidyl)methyl)benzofuro(2,3-C)pyridine derivatives, and their application in therapy

A compound of formula (I) STR1 in which R is a benzyl, benzoyl, 3-chlorobenzoyl, 3-methylbenzoyl or (C1 -C6 alkoxy)carbonyl group, or a pharmacologically acceptable acid addition salt thereof.

2-[(4-PIPERIDYL)METHYL]-1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, AND THEIR APPLICATION IN TREATING DEPRESSIVE STATE, ANXIETY STATE OR HYPERTENSION

A compound which is a pyrido[3,4-b]derivative of formula (I) STR1 in which R is a hydrogen atom or an alkyl carbonyl, arylalkylcarbonyl or arylcarbonyl group of formula COR 1 wherein R. sub.1 is a C 1-C. sub.6 alkyl group, a benzyl group or a phenyl group unsubstituted or substituted with 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, C 1-C 3 alkyl and C 1-C. sub.3 alkoxy groups or R is an alkoxycarbonyl or benzyloxycarbonyl group of formula COOR 2 wherein R 2 is a C 1-C 6 alkyl group or a benzyl group, or R is a substituted aminocarbonyl group of formula CONHR 3 wherein R 3 is a C 1-C 6 alkyl group or a phenyl group, or R is an arylsulphonyl group of formula SO 2 R. sub.4 wherein R 4 is a phenyl group, or a pharmacologically acceptable acid addition salt thereof useful for treating hypertension, depressive state or anxiety state.

2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy

A compound of formula (I) STR1 in which R is (a) a hydrogen atom; (b) a linear or branched (C1 -C6) alkyl group; an allyl group; a cycloalkylmethyl group in which the cycloalkyl moiety has from 3 to 6 carbon atoms; a phenylmethyl group unsubstituted or substituted with one to three substituents chosen from halogen atoms and trifluoromethyl, nitro, amino, dimethylamino, cyano, aminocarbonyl, linear or branched (C1 -C3) alkyl, linear or branched (C1 -C3) alkoxy and linear or branched (C1 -C3) alkylthio groups; a 2-phenylethyl group; a 3-phenylpropyl group; a 3-phenyl-2-propenyl group; a phenylcarbonylmethyl group; a naphthylmethyl group; a pyridylmethyl group; a furylmethyl group; or a thienylmethyl group; or (c) a linear or branched (C2 -C6) alkanoyl group; a cycloalkylcarbonyl group in which the cycloalkyl moiety has from 3 to 6 carbon atoms; a trifluoroacetyl group; a phenyl-carbonyl group unsubstituted or substituted with one to three substituents chosen from halogen atoms and trifluoromethyl, nitro, linear or branched (C1 -C3) alkyl, linear or branched (C1 -C3) alkoxy and linear or branched (C1 -C3) alkylthio groups; a 1-oxo-3-phenyl-2-propenyl group; a naphthylcarbonyl group; a pyridylcarbonyl group; a furylcarbonyl group; a thienylcarbonyl group; a (2-indolyl)-carbonyl group; or a (5-indolyl)carbonyl group; or a pharmacologically acceptable acid addition salt thereof.