1208500-46-2Relevant academic research and scientific papers
Iodine/Palladium approaches to the synthesis of polyheterocyclic compounds
Mehta, Saurabh,Larock, Richard C.
supporting information; experimental part, p. 1652 - 1658 (2010/05/01)
Chemical Equation Represented A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I2 or ICI. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently incorporated under mild reaction conditions. In addition, variations of this strategy afford a variety of linked and fused PHCs.
