Cas 1208672-46-1,5-Isothiocyanato-2-(trifluoromethyl)pyridine

1208672-46-1

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Basic information

Product Name: 5-Isothiocyanato-2-(trifluoromethyl)pyridine
Synonyms: 5-Isothiocyanato-2-(trifluoromethyl)pyridine
CAS NO:1208672-46-1
Molecular Formula: C7H3F3N2S
Molecular Weight: 204.1723296
EINECS: N/A
Product Categories: N/A
Mol File: 1208672-46-1.mol
Article Data: 3

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: /
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 5-Isothiocyanato-2-(trifluoromethyl)pyridine(CAS DataBase Reference)
NIST Chemistry Reference: 5-Isothiocyanato-2-(trifluoromethyl)pyridine(1208672-46-1)
EPA Substance Registry System: 5-Isothiocyanato-2-(trifluoromethyl)pyridine(1208672-46-1)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: IRRITANT
PackingGroup: N/A
Hazardous Substances Data: 1208672-46-1(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1208672-46-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,6,7 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1208672-46:
(9*1)+(8*2)+(7*0)+(6*8)+(5*6)+(4*7)+(3*2)+(2*4)+(1*6)=151
151 % 10 = 1
So 1208672-46-1 is a valid CAS Registry Number.

1208672-46-1Upstream product

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1208672-46-1Relevant articles and documents

THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE

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Paragraph 399, (2020/01/11)

Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

N-aryl-2-aminobenzimidazoles: Novel, efficacious, antimalarial lead compounds

Ramachandran, Sreekanth,Hameed P., Shahul,Srivastava, Abhishek,Shanbhag, Gajanan,Morayya, Sapna,Rautela, Nikhil,Awasthy, Disha,Kavanagh, Stefan,Bharath, Sowmya,Reddy, Jitendar,Panduga, Vijender,Prabhakar,Saralaya, Ramanatha,Nanduri, Robert,Raichurkar, Anandkumar,Menasinakai, Sreenivasaiah,Achar, Vijayashree,Jiménez-Díaz, María Belén,Martínez, María Santos,Angulo-Barturen, I?igo,Ferrer, Santiago,Sanz, Laura María,Gamo, Francisco Javier,Duffy, Sandra,Avery, Vicky M.,Waterson, David,Lee, Marcus C. S.,Coburn-Flynn, Olivia,Fidock, David A.,Iyer, Pravin S.,Narayanan, Shridhar,Hosagrahara, Vinayak,Sambandamurthy, Vasan K.

, p. 6642 - 6652 (2014/10/15)

From the phenotypic screening of the AstraZeneca corporate compound collection, N-aryl-2-aminobenzimidazoles have emerged as novel hits against the asexual blood stage of Plasmodium falciparum (Pf). Medicinal chemistry optimization of the potency against Pf and ADME properties resulted in the identification of 12 as a lead molecule. Compound 12 was efficacious in the P. berghei (Pb) model of malaria. This compound displayed an excellent pharmacokinetic profile with a long half-life (19 h) in rat blood. This profile led to an extended survival of animals for over 30 days following a dose of 50 mg/kg in the Pb malaria model. Compound 12 retains its potency against a panel of Pf isolates with known mechanisms of resistance. The fast killing observed in the in vitro parasite reduction ratio (PRR) assay coupled with the extended survival highlights the promise of this novel chemical class for the treatment of malaria.

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