120882-22-6 Usage
Description
Desfuroyl Ceftiofur is a microbiologically active metabolite of Ceftiofur (C244700), a broad-spectrum cephalosporin antibiotic. It is a white solid and is formed as a primary hydrolysis product. Desfuroyl Ceftiofur possesses antimicrobial properties, making it a valuable compound in the field of medicine, particularly for treating bacterial infections.
Uses
Used in Pharmaceutical Industry:
Desfuroyl Ceftiofur is used as an antimicrobial agent for the treatment of various bacterial infections. Its microbiological activity allows it to target and eliminate harmful bacteria, providing a therapeutic solution for patients suffering from such infections.
Used in Veterinary Medicine:
In the veterinary medicine industry, Desfuroyl Ceftiofur is used as an antibiotic to treat bacterial infections in animals. Its broad-spectrum activity ensures that a wide range of bacterial pathogens can be effectively managed, contributing to the overall health and well-being of animals under treatment.
Used in Research and Development:
Desfuroyl Ceftiofur is also utilized in research and development as a key compound for studying the properties and mechanisms of action of cephalosporin antibiotics. Its role as a metabolite of Ceftiofur makes it an important subject for understanding the pharmacokinetics and pharmacodynamics of the parent drug, which can lead to the development of more effective and targeted antimicrobial therapies in the future.
Check Digit Verification of cas no
The CAS Registry Mumber 120882-22-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,8,8 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 120882-22:
(8*1)+(7*2)+(6*0)+(5*8)+(4*8)+(3*2)+(2*2)+(1*2)=106
106 % 10 = 6
So 120882-22-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H15N5O5S3/c1-24-18-7(6-4-27-14(15)16-6)10(20)17-8-11(21)19-9(13(22)23)5(2-25)3-26-12(8)19/h4,8,12,25H,2-3H2,1H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7+/t8-,12-/m1/s1
120882-22-6Relevant articles and documents
Controlled hydrolysis of ceftiofur sodium, a broad-spectrum cephalosporin; isolation and identification of hydrolysis products
Koshy, K. Thomas,Cazers, Alexander R.
, p. 389 - 395 (1997)
Ceftiofur sodium is the salt of (6R,7R)-7-{[(2-amino-4-thiazoyl)-Z- (methoxyimino)acetyl]amino}-3-{[(2-furanylcarbonyl)thio]methyl}-8-oxo-5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. This compound is very susceptible to acid, alkaline-, and enzyme-catalyzed hydrolysis, producing a number of unstable degradation products. In this report, we describe the preparation and identification of the hydrolysis products that are formed under controlled alkaline conditions. The primary hydrolysis product was desfuroyl ceftiofur, which is the most abundant metabolite in bovine blood. Desfuroyl ceftiofur was carefully oxidized with H2O2 to prepare the disulfide dimer, a urinary metabolite of ceftiotur sodium in the rat and cattle. Under acidic conditions, desfuroyl ceftiofur was converted to the corresponding thiolactone. The preparation of desacetyl cefotaxime, which is the oxygen analog of desfuroyl ceftiofur, is also described. Furoic acid was readily formed by hydrolytic cleavage of the thioester bond. Thiofuroic acid, formed by the less common cleavage on the alkyl side of the thioester bond, was also isolated.
