1208865-01-3Relevant articles and documents
Enantioselective michael addition to α,β-Unsaturated aldehydes: Combinatorial catalyst preparation and screening, reaction optimization and mechanistic studies
Fleischer, Ivana,Pfaltz, Andreas
supporting information; experimental part, p. 95 - 99 (2010/03/26)
Shortcut to chiral catalysts: An efficient combinatorial strategy based on back reaction screening by ESI-MS allows rapid evaluation of organocatalysis for the asymmetric Michael addition to α,β-unsaturated aldehydes (see scheme). An unexpected nonlinear effect has been observed in this reaction, resulting from a double nucleophilic-electrophilic activation mechanism involving two catalyst molecules "Chemical Equation Presented"