1208940-79-7Relevant academic research and scientific papers
Chiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct
Zhang, Yun,Ao, Yu-Fei,Huang, Zhi-Tang,Wang, De-Xian,Wang, Mei-Xiang,Zhu, Jieping
, p. 5282 - 5285 (2016)
Reaction of isonitriles with 3-(arylamino)isobenzofuran-1(3H)-ones in the presence of a catalytic amount of an octahydro (R)-binol-derived chiral phosphoric acid afforded 3-oxo-2-arylisoindoline-1-carboxamides in high yields with good to high enantioselec
Isolation of Ugi four-component condensation primary adducts: A straightforward route to isocoumarins
Faggi, Cristina,Garcia-Valverde, Maria,Marcaccini, Stefano,Menchi, Gloria
supporting information; experimental part, p. 788 - 791 (2010/04/06)
(Chemical Equation Presented) Ugi four-component condensation (Ugi-4CC) between 2-formylbenzoic acid, phenacylamine dimethyl acetal, and isocyanides afforded 1H-isochromen-1-ones (isocoumarins). These products, where structure corresponds to the tautomeric enediamine form of the Ugi-4CC primary adducts, were stable enough to allow their isolation and characterization. Stable isocoumarins were also obtained by employing anilines as the amino component In the Ugi four-component condensation.
