1208977-13-2Relevant academic research and scientific papers
SPIROPIPERIDINE BENZYLAMINES AS BETA-TRYPTASE INHIBITORS
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, (2011/07/09)
The present invention discloses and claims a series of substituted spiropiperidine benzylamines of formula (I) wherein R is as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as
[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-ETHYL)-4-TRIFLUOROMETHOXY-1H-INDOL-3-YL]-METHANONE AS AN INHIBITOR OF MAST CELL TRYPTASE
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Page/Page column 28; 31; 43-44, (2010/04/03)
The present invention is directed to an indole benzylamine compound useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from,or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient a therapeutically effective amount of the compound. Furthermore, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I,and a pharmaceutically acceptable carrier.
