1208988-83-3Relevant academic research and scientific papers
Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
-
Page/Page column 179; 180; 181; 182, (2016/09/26)
The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
A notable conversion of a thiolacetate to its corresponding sulfonyl chloride
Huang, Yuhua,Bennett, Frank,Verma, Vishal,George Njoroge,MacCoss, Malcolm
scheme or table, p. 3203 - 3205 (2012/08/07)
A direct conversion of a thiolacetate to its corresponding sulfonyl chloride in the presence of acid and base sensitive functional groups is described.
SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS
-
Page/Page column 203, (2010/04/03)
The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
