1208999-01-2Relevant academic research and scientific papers
Attempted cycloaromatization of α-arylmethyl sulfones with 2-bis(methylthio)methylene-1-tetralone: Unexpected formation of 2-aryl-3-(methylthio)-4,5-dihydronaphtho[1,2-b]furans
Nandi, Sukumar,Kumar, Sarvesh,Ila, Hiriyakkanavar,Junjappa, Hiriyakkanavar
experimental part, p. 22 - 31 (2010/09/05)
Base-induced conjugate addition-elimination of α-arylmethyl sulfones to α-oxoketene dithioacetal 1 followed by acid-induced cyclization affords 2-phenyl-3-(methylthio)-4,5-dihydronaphtho[1,2-b]furans which could be converted to parent aromatized products by DDQ dehydrogenation followed by Raney-Ni dethiomethylation. The approach was found to be amenable to a variety of sulfone components.
