1209-03-6

Basic information

• Product Name: 4-[2-(2-pyridinyl)ethenyl]phenol
• Synonyms: 4-[2-(2-pyridinyl)ethenyl]phenol
• CAS NO: 1209-03-6
• Molecular Weight: 197.236
• Mol File: 1209-03-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-[2-(2-pyridinyl)ethenyl]phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(2-pyridinyl)ethenyl]phenol(1209-03-6)
• EPA Substance Registry System: 4-[2-(2-pyridinyl)ethenyl]phenol(1209-03-6)

Safety Data

• Hazardous Substances Data: 1209-03-6(Hazardous Substances Data)

Usage

General Description

4-[2-(2-pyridinyl)ethenyl]phenol is a chemical compound with the molecular formula C17H13NO. It is a synthetic derivative of phenol that contains a pyridine ring and an ethenyl functional group. 4-[2-(2-pyridinyl)ethenyl]phenol is used in pharmaceutical research and development, particularly in the study of potential drug candidates for conditions such as cancer and neurological disorders. Its structure and properties make it a potential candidate for drug design and discovery, as it may have the ability to interact with specific biological targets and pathways. Further research is needed to fully understand the potential uses and effects of 4-[2-(2-pyridinyl)ethenyl]phenol in medical and pharmaceutical applications.

Upstream product

• 1149-57-1 4-[2-(2-pyridinyl)ethenyl]phenyl acetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 109-06-8 α-picoline 

Downstream Products

• 801219-35-2 2-HHSP 
• 1257420-05-5 4-(6-(4-(2-(2-pyridinyl)vinyl)phenoxy)hexyloxy)aniline 
• 1257420-04-4 t-butyl 4-(6-(4-(2-(2-pyridinyl)vinyl)phenoxy)hexyloxy)phenylcarbamate 
• 1257420-03-3 2-(4-(6-bromohexyloxy)styryl)pyridine 
• 1257420-06-6 2-(4-(6-(4-nitrophenoxy)hexyloxy)styryl)pyridine 
• 1346230-93-0 C₃₂H₃₂N₂O₂ 
• 1346230-95-2 C₃₄H₃₆N₂O₂ 
• 1346230-97-4 C₃₅H₃₈N₂O₂ 

Relevant articles and documents

Design, synthesis and biological evaluation of pyrimidine-based derivatives as VEGFR-2 tyrosine kinase inhibitors

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has already become an attractive approach for cancer therapy. In this study, a novel pyrimidine-based derivative 7j was designed as lead compound, and three series of potent VEGFR-2 inhibitors were synthesized and biologically evaluated against A549 and HepG2 cell lines. Compounds 7d, 9s and 13n exhibited superior inhibitory activities against A549 cell with IC50 ranged from 9.19 to 13.17 μM and HepG2 cell with IC50 ranged from 11.94 to 18.21 μM compared to those of Pazopanib (IC50 = 21.18 and 36.66 μM). In addition, molecular docking study was performed to investigate the binding capacity and binding mode between target compounds and VEGFR-2.

Synthesis of new conjugated polymers as hole injection layer and performance of OLED devices

The fluorene-based poly(dioctylfluorene-alt-biphenylamine)s with styrylpyridyl group were synthesized by using Pd-catalyzed polycondensation reaction. These hole injection/ transport polymers showed very good solvent resistance after photo-crosslinking which could facilitate the subsequent spin coating of the emitting layer polymer solution. Moreover these polymers could be patterned by using distyrylpyridyl alkyl monomer (DSM) as crosslinking agents. The OLED devices with configuration of ITO/HIL/Alq3:NPD/LiF/Al in which synthesized polymer was used as hole injection layer (HIL) were fabricated and their performance was compared with the commercially available PEDOT:PSS as HIL layer.

Synthesis and photolithographic property of conjugated polymers with polyazomethine structure

Two different polyazomethine-type conjugated polymers, poly(phenoxiazine-3, 3′-dihydroxybensidine)(PZ-DHB) and poly(phenoxiazine-2,4-diamino-6- hydroxypyrimidine)(PZ-DHP) containing phenothiazine moiety and azomethine linkage in the main chain were synthe