120929-99-9Relevant academic research and scientific papers
On Triazoles XVI . The Reaction of 5-Amino-1,2,4-triazoles with β- and γ-Oxo Esters. A Novel N-Carbonylation Reaction
Reiter, Jozsef,Vago, Pal,Esses-Reiter, Klara,Pongo, Laszlo,Molnar, Hilda
, p. 1751 - 1755 (2007/10/02)
5-Amino-1,2,4-triazoles reacted with alifatic β-oxo-esters to yield besides the unexpected 1,2,4-triazolo-1,3,5-benzotriazepin-5-one derivative 7 either the corresponding esters 5 and 6 or a 1:2 condensation product 8.To the contrary alicyclic and heterocyclic β-oxo-esters formed in the above reaction only derivatives 7.The proposed mechanism of the formation of 7 involving a novel N-carbonylation reaction was proved by the isolation of the by-products and the intermediate of the reaction.Repeating the above reaction with γ-oxo-esters, namely the ethyl levulinate, derivatives 17 and 18, respectively, representing two new ring systems were obtained.
