120935-87-7

Upstream product

• 4755-81-1 methyl 2-chloroacetoacetate 
• 120935-85-5 1-<2-(phenylmethyl)benzoyl>-1,3-pentanedione 
• 950203-40-4 methyl 3-tert-butoxycarbonylazo-2-butenoate 
• 120935-86-6 methyl 1-(((1,1-Dimethylethoxy)carbonyl)amino)-5-ethyl-2-methyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

Azoalkene route to methyl 2,5-dimethyl-4[2-(phenylmethyl)benzoyl]-1H- pyrrole-3-carboxylate (FPL 64176) and analogues: Synthesis of 1-(BOC- amino)pyrrole-3-carboxylates and their conversion to 1H-pyrroles via 1- aminopyrroles

A new route to the calcium channel activator methyl 2,5-dimethyl-4[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues is presented. Reaction of activated diones with BOC-azoalkenes gave pyrroles with the required functionality bu

Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them

Compounds of formula I, wherein, R1, R2, R3 and R5 have the meanings defined in the specification,G2 represents a chain -(CH2)z(W)y-, in which W has various meanings including C=O, and up to two of the methylene segments in the chain (CH2)zare optionally replaced by -NH- and one segment is optionally replaced by -O- or -(C=NR40)-, and the chain is optionally unsaturated and optionally substituted, and, A is a 5- or 6-membered ring or a bicyclic or tricyclic fused ring system, A being optionally substituted by various substituents,possess useful pharmacological properties, in particular as cardiotonics. Also described are processes for the preparation of compounds of formula I, pharmaceutical compositions containing them and methods of treatment involving their use.