120935-94-6

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 4-BROMO-2,5-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE is used as a precursor for the synthesis of intermediates in the development of pharmaceuticals. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, METHYL 4-BROMO-2,5-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE is used as a starting material for the preparation of organic compounds with pesticidal or herbicidal properties. Its versatility in synthesis enables the development of new agrochemicals to address various agricultural challenges.
Used in Materials Science:
METHYL 4-BROMO-2,5-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE is utilized in materials science for the synthesis of novel materials with specific properties. Its unique structure can contribute to the development of advanced materials for various applications, such as electronics, coatings, or adhesives.
Used in Research and Development:
In the field of research and development, METHYL 4-BROMO-2,5-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE serves as a valuable starting material for the preparation of organic compounds. Its reactivity and structural features make it an attractive candidate for exploring new synthetic pathways and discovering innovative compounds with potential applications in various industries.

InChI:InChI=1/C8H10BrNO2/c1-4-6(8(11)12-3)7(9)5(2)10-4/h10H,1-3H3

Upstream product

• 69687-80-5 methyl 2,5-dimethyl-1H-pyrrole-3-carboxylate 
• 39416-48-3 pyridinium hydrobromide perbromide 

Downstream Products

• 1320232-56-1 methyl 1-benzyl-2,5-dimethyl-4-phenyl-1H-pyrrole-3-carboxylate 
• 562072-83-7 4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonitrile 
• 1354900-61-0 1-benzyl-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonitrile 
• 894075-10-6 ethyl 2-chloro-5-{[3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl]methyl}pyridine-3-carboxylate 
• 894073-97-3 1-{[6-chloro-5-(hydroxymethyl)pyridin-3-yl]methyl}-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonitrile 
• 1354900-62-1 1-{[5-(hydroxymethyl)pyridin-3-yl]methyl}-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonitrile 
• 120935-96-8 methyl 2,5-dimethyl-4-<2-(phenylmethyl)benzoyl>-1-<<2-(trimethylsilyl)ethoxy>methyl>-1H-pyrrole-3-carboxylate 
• 120934-96-5 methyl 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists

A series of 4-phenylpyrrole derivatives D were designed, synthesized, and evaluated for their potential as novel orally available androgen receptor antagonists therapeutically effective against castration-resistant prostate cancers. 4-Phenylpyrrole compou

ANDROGEN RECEPTOR ANTAGONISTS

The present invention provides an androgen receptor antagonistic agent and a superior prophylactic or therapeutic agent for hormone-sensitive cancer, which contain a compound of the formula: wherein, R1 is a hydrogen atom, a group binding through a carbon atom, a group binding through a nitrogen atom, a group binding through an oxygen atom or a group binding through a sulfur atom; R2 is a hydrogen atom, a group binding through a carbon atom, a group binding through a nitrogen atom, a group binding through an oxygen atom or a group binding through a sulfur atom, R3 is a hydrogen atom, a hydrocarbon group which may have substituent (s) , an acyl group or a heterocyclic group which may have substituent(s), R4 is a hydrogen atom, a group binding through a carbon atom, a group binding through a nitrogen atom, a group binding through an oxygen atom or a group binding through a sulfur atom, and R5 is a cyclic group which may have substituent(s); or a salt thereof, or its prodrug.

Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: The first examples of a new class of calcium channel activator

Methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate, FPL 64176 (1), is the first example of a new class of calcium channel activator (CCA) that does not act on any of the well-defined calcium channel modulator receptor sites, as typif

Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them

Compounds of formula I, wherein, R1, R2, R3 and R5 have the meanings defined in the specification,G2 represents a chain -(CH2)z(W)y-, in which W has various meanings including C=O, and up to two of the methylene segments in the chain (CH2)zare optionally replaced by -NH- and one segment is optionally replaced by -O- or -(C=NR40)-, and the chain is optionally unsaturated and optionally substituted, and, A is a 5- or 6-membered ring or a bicyclic or tricyclic fused ring system, A being optionally substituted by various substituents,possess useful pharmacological properties, in particular as cardiotonics. Also described are processes for the preparation of compounds of formula I, pharmaceutical compositions containing them and methods of treatment involving their use.