120943-80-8

Basic information

• Product Name: (E)-1-(tert-butyldimethylsilyl)-3-(p-nitrophenyl)-2-propen-1-one
• CAS NO: 120943-80-8
• Molecular Weight: 291.422
• Mol File: 120943-80-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(tert-butyldimethylsilyl)-3-(p-nitrophenyl)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(tert-butyldimethylsilyl)-3-(p-nitrophenyl)-2-propen-1-one(120943-80-8)
• EPA Substance Registry System: (E)-1-(tert-butyldimethylsilyl)-3-(p-nitrophenyl)-2-propen-1-one(120943-80-8)

Safety Data

• Hazardous Substances Data: 120943-80-8(Hazardous Substances Data)

Upstream product

• 120943-69-3 1-(tert-butyldimethylsilyl)-2-iodo-1-ethanone 
• 120820-58-8 2-bromo-1-tert-butyldimethylsilyl-1-ethanone 
• 555-16-8 4-nitrobenzaldehdye 
• 120943-70-6 dimethyl <2-(tert-butyldimethylsilyl)-2-oxoethyl>-phosphonate 

Relevant articles and documents

Application of (α-Phosphonoacyl)silane Reagents to the Synthesis of α,β-Unsaturated Acylsilanes

An efficient and convergent synthetic route to α,β-unsaturated acylsilanes has been developed based on the Horner-Wadsworth-Emmons reaction of (α-phosphonoacyl)silanes.The Arbuzov reaction of the (α-iodoacyl)silane 1c with trimethyl phosphite provides access to the phosphonate 2, which can be alkylated by treatment with potassium tert-butoxide and methyl iodide to afford 3.These (α-phosphonoacyl)silane reagents combine smoothly with a variety of aldehydes to furnish α,β-unsaturated acylsilanes 5-13 in good to excellent yield.