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HIV PROTEASE SUBSTRATE II, also known as H-Arg-Arg-Val-Leu-Lys(NO2)-Pro-Ile-Val-Glu-Val-Val-Glu-Ala-Phe-Pro-Lys(NO2)-NH2, is a synthetic peptide specifically designed to serve as a substrate for the enzyme HIV protease. This substrate is instrumental in laboratory research, enabling the study of HIV protease activity and the development of inhibitors crucial for combating the human immunodeficiency virus (HIV). The unique amino acid sequence of HIV PROTEASE SUBSTRATE II is recognized and cleaved by HIV protease, providing a means to evaluate the potency of potential anti-HIV drugs and to understand the enzyme's mechanisms.

120944-74-3

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120944-74-3 Usage

Uses

Used in Pharmaceutical Research and Development:
HIV PROTEASE SUBSTRATE II is used as a laboratory tool for assessing the activity of HIV protease. It aids researchers in understanding the enzyme's role in HIV replication and in identifying potential anti-HIV drugs by monitoring the substrate's cleavage.
Used in HIV Drug Screening:
HIV PROTEASE SUBSTRATE II is utilized as a substrate in high-throughput screening assays to test the efficacy of new compounds against HIV protease. This process is vital for the discovery and optimization of antiretroviral drugs that can inhibit the enzyme and, consequently, hinder the virus's ability to replicate.
Used in Structural Biology:
In the field of structural biology, HIV PROTEASE SUBSTRATE II is employed to study the three-dimensional structure of HIV protease and its interactions with inhibitors. This information is critical for designing drugs that can effectively bind to and inhibit the enzyme, thus providing therapeutic benefits in treating HIV infections.
Used in Diagnostics:
HIV PROTEASE SUBSTRATE II can be applied in diagnostic assays to detect the presence of active HIV protease in patient samples. This can help in monitoring the progression of HIV infection and the effectiveness of ongoing treatments.
Used in Educational Settings:
As an illustrative tool in educational settings, HIV PROTEASE SUBSTRATE II is used to demonstrate the principles of enzyme kinetics, substrate specificity, and the mechanisms of action of antiviral drugs to students in biology, biochemistry, and medical curricula.

Check Digit Verification of cas no

The CAS Registry Mumber 120944-74-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,9,4 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 120944-74:
(8*1)+(7*2)+(6*0)+(5*9)+(4*4)+(3*4)+(2*7)+(1*4)=113
113 % 10 = 3
So 120944-74-3 is a valid CAS Registry Number.

120944-74-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name HIV PROTEASE SUBSTRATE II

1.2 Other means of identification

Product number -
Other names HIV SUBSTRATE II

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120944-74-3 SDS

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