120959-22-0Relevant academic research and scientific papers
Synthesis and antiulcer activity of N-substituted N'-[3-[3- (piperidinomethyl)phenoxy]propyl]ureas: Histamine H2-receptor antagonists with a potent mucosal protective activity
Miyashita,Matsumoto,Matsukubo,Iinuma,Taga,Sekiguchi,Hamada,Okamura,Nishino
, p. 2446 - 2451 (2007/10/02)
As an aim toward developing new antiulcer agents, new N-substituted N'-[3- [3-(piperidinomethyl)phenoxy]propyl]ureas were synthesized and evaluated for histamine H2-receptor antagonistic, gastric antisecretory, and gastric mucosal protective activities. A QSAR study showed that the most favorable N- substituents were electron-donating straight-chain alkyl groups of short length such as ethyl group from the viewpoint of dual action, i.e., gastric antisecretory and mucosal protective actions. Among the ureas studied, compounds 4, 5, and 8-10 were selected as candidates for further study.
Anti-ulcer urea derivatives
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, (2008/06/13)
Urea derivatives of the following formula, STR1 wherein R1 indicates a piperidino group or pyrrolidino group which may be substituted with hydroxy group or lower alkyl group having 1 to 3 carbon atoms; A indicates an ethylene group, propylene group, butylene group or butenylene group; R2 indicates a straight or branched alkyl group having 1 to 20 carbon atoms, cycloalkyl group having 3 to 6 carbon atoms, benzyl group, or phenyl group which may have 1 to 3 substituents such as lower alkyl group having 1 to 6 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, halogen atom, trifluoromethyl group, amino group, nitro group or methylenedioxy group; X indicates an oxygen or sulfur atom, the hydrates and pharmaceutically acceptable acid addition salts thereof are useful as antiulcer agents.
