120962-18-7Relevant academic research and scientific papers
Stereocontrolled Total Synthesis of Pancratistatin
Kim, Sanghee,Ko, Hyojin,Kim, Eunkyung,Kim, Deukjoon
, p. 1343 - 1345 (2002)
(Matrix Presented) A new total synthesis of the antitumor alkaloids, pancratistatin (1), has been accomplished from readily available staring materials. The Claisen rearrangement of dihydropyranethylene 5 was employed to construct the A and C rings. Stere
Total Synthesis of Pancratistatin Relying on the [3,3]-Sigmatropic Rearrangement
Ko, Hyojin,Kim, Eunkyung,Park, Jae Eun,Kim, Deukjoon,Kim, Sanghee
, p. 112 - 121 (2004)
A new total synthesis of the antitumor alkaloid, pancratistatin (1), has been accomplished from readily available starting materials. Claisen rearrangement of the racemic dihydropyranethylene 17 was employed to construct the A and C rings with the appropr
β-silyl styrene as a dienophile in the cycloaddition with 3,5-dibromo-2-pyrone for the total synthesis of (±)-pancratistatin
Jung, Yong-Geun,Kang, Ho-Ung,Cho, Hyun-Kyu,Cho, Cheon-Gyu
, p. 5890 - 5892 (2011)
A new synthetic route to (±)-pancratistatin was devised utilizing β-silyl styrene as a dienophile in the cycloaddition with 3,5-dibromo-2-pyrone. The TMS group incorporated in the cycloadduct permitted a facile elimination process for the eventual install
Total synthesis of (±)-pancratistatin
Danishefsky,Lee
, p. 4829 - 4837 (2007/10/02)
The total synthesis of the antitumor title compound has been accomplished. Among the key steps was an iodolactonization of a cyclohexadiene bearing a neighboring carboxamido group mediated by an ortho-stannylated phenol. A series of cis vicinal functional
