120990-68-3

Basic information

• Product Name: 11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperidin-1-yl}-acetyl)-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
• Synonyms: 11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperidin-1-yl}-acetyl)-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
• CAS NO: 120990-68-3
• Molecular Weight: 461.607
• Mol File: 120990-68-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperidin-1-yl}-acetyl)-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperidin-1-yl}-acetyl)-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one(120990-68-3)
• EPA Substance Registry System: 11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperidin-1-yl}-acetyl)-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one(120990-68-3)

Safety Data

• Hazardous Substances Data: 120990-68-3(Hazardous Substances Data)

Upstream product

• 885-70-1 5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one 
• 28797-48-0 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 
• 121053-96-1 Cyclohexyl-methyl-piperidin-2-ylmethyl-amine 

Relevant articles and documents

Tricyclic Compounds as Selective Muscarinic Receptor Antagonists. 3. Structure-Selectivity Relationships in a Series of Cardioselective (M2) Antimuscarinics

On the basis of the cardioselective muscarinic receptor antagonist AF-DX 116 (2), a series of 11-substituted pyridobenzodiazepinones (9-35) was prepared and screened for their binding affinity to muscarinic receptors located in cardiac (M2) and glandular (M3) tissue.The ratio of IC50 values of the test compounds in the two different tissues was taken as a measure of cardiac (M2) receptor selectivity.Qualitative structure-selectivity relationships point to the fact that it is the spartial orientation of the protonated side-chain nitrogen atom in relation to the tricycle that is the main determinant for receptor subtype recognition and hence is important for the achievement of cardiac (M2) selectivity.