120991-60-8

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl]-
• Synonyms: 1H-Isoindole-1,3(2H)-dione, 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl]-
• CAS NO: 120991-60-8
• Molecular Formula: C₂₃H₂₈N₂O₃
• Molecular Weight: 380.48002
• Mol File: 120991-60-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 518.3°Cat760mmHg
• Flash Point: 267.2°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 7.6E-11mmHg at 25°C
• Refractive Index: 1.576
• PKA: 9.52±0.50(Predicted)
• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl]-(120991-60-8)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl]-(120991-60-8)

Safety Data

• Hazardous Substances Data: 120991-60-8(Hazardous Substances Data)

Usage

General Description

1H-Isoindole-1,3(2H)-dione, 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl]- is a chemical compound with the molecular formula C26H32N2O3. Its structure consists of a central isoindole-1,3(2H)-dione core with a 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl] side chain attached to it. 1H-Isoindole-1,3(2H)-dione, 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl]- is a derivative of isoindole and contains a substituted amino group, a methoxy phenyl group, and a butyl chain. It is likely to have biological activity or potential therapeutic properties due to its structural features and the presence of the amino group. 1H-Isoindole-1,3(2H)-dione, 2-[4-[[3-(2-methoxyphenyl)propyl]methylamino]butyl]- may be of interest in the fields of pharmacology, medicinal chemistry, and drug discovery.

InChI:InChI=1/C23H28N2O3/c1-24(16-9-11-18-10-3-6-14-21(18)28-2)15-7-8-17-25-22(26)19-12-4-5-13-20(19)23(25)27/h3-6,10,12-14H,7-9,11,15-17H2,1-2H3

Upstream product

• 120991-80-2 N-<3-(2-methoxyphenyl)propyl>-1,4-diaminobutane 
• 18655-51-1 2-(3-Aminopropyl)-1-methoxybenzene 
• 1504-74-1 2-methoxycinnamaldehyde 
• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 85-44-9 phthalic anhydride 
• 64-18-6 formic acid 
• 120991-58-4 N-<4-(2-phthalimido)butyl>-3-(2-methoxyphenyl)-1-aminopropane 

Relevant articles and documents

N-(Phthalimidoalkyl) Derivatives of Serotonergic Agents: A Common Interaction at 5-HT1A Serotonin Binding Sites ?

Several classes of agents are known to bind at central 5-HT1a serotonin sites.In order to challenge the hypothesis that these agents bind in a relatively similar manner (i.e., share common aryl and terminal amine sites), we prepared N-(phthalimidobutyl) derivatives of examples of several such agents.With regard to arylpiperazines, we had previously shown that introduction of this functionality at the terminal amine is tolerated by the receptor and normally results in a significant (>10-fold) enhancement in affinity.The results of the present study show that this bulky functionality is also tolerated by the receptor when incorporated into examples of all other major classes of 5-HT1A agents (e.g., 2-aminotetralin, phenylalkylamine, indolylalkylamine, and (aryloxy)alkylamine derivatives).The length of the alkyl chain that separates the terminal amine from the phthalimido group is of major importance, and a four-carbon chain appears optimal.Alteration of the length of this chain can have a significant influence on affinity; decreasing the chain length from four to three carbon atoms can reduce affinity by an order of magnitude, and further shortening can have an even more pronounced effect.