120996-43-2Relevant articles and documents
Synthesis and Reactions of 4,6-Diaryl-2,3,4,5-tetrahydropyridazin-3-ones
Sayed, M. A.,El-Khamry, A. A.,Soliman, A. Y.,Afify, A. A.,Kassab, E. A.
, p. 1 - 13 (2007/10/03)
The hitherto unknown 4,6-diaryl-2,3,4,5-tetrahydro-pyridazin-3-ones IIIa-e were synthesized from the α-aryl,β-aroylpropionic acid IIa-e either by their reaction with hydrazine hydrate or by their conversion to α, γ-diaryl-Δβ,γ-butenolides (XI), and treatment of the latter with hydrazine hydrate, III afforded 3-chloropyridazin derivative (IV) on its reaction with POCl3, PCl5.The 3-chloropyridazine was treated either with sodium azide producing the tetrazolopyridazine derivative (V) or with acylhydrazines to give the triazolopyridazine derivatives (VIa-c). 3-Acylpyridazines (VII)a and b were obtained on treatment of III with acyl chlorides.IIIa was converted to its corresponding thione (VIII), also reacted with benzyl-amine giving 3-N-benzylpyridazine (IX).IIIa was dehydrogenated to the corresponding dihydropyridazinone (X).