121000-76-8Relevant academic research and scientific papers
A Straightforward Homologation of Carbon Dioxide with Magnesium Carbenoids en Route to α-Halocarboxylic Acids
Monticelli, Serena,Urban, Ernst,Langer, Thierry,Holzer, Wolfgang,Pace, Vittorio
supporting information, p. 1001 - 1006 (2019/01/30)
The homologation of carbon dioxide with stable, (enantiopure) magnesium carbenoids constitutes a valuable method for preparing α-halo acid derivatives. The tactic features a high level of chemocontrol, thus enabling the synthesis of variously functionalized analogues. The flexibility to generate magnesium carbenoids through sulfoxide-, halogen- or proton- Mg exchange accounts for the wide scope of the reaction. (Figure presented.).
A Novel Synthesis Including Asymmetric Synthesis of α,β-Unsaturated γ-Hydroxy Carbonyl Compounds from Enones with Carbon Homologation
Satoh, Tsuyoshi,Motohashi, Shigeyasu,Tokutake, Norio,Yamakawa, Koji
, p. 2966 - 2973 (2007/10/02)
Reaction of the carbanion derived from 1-chloroalkyl aryl sulfoxides with enones gave 1,2-adducts in good yields.Treatment of the adduct with potassium benzenethiolate afforded α-phenylthio β,γ-unsaturated carbonyl compound through an α,β-epoxy sulfoxide.
SELECTIVITIES OF α-HALOSULFINYL CARBANIONS TOWARDS ENONES
Mahidol, Chulabhorn,Reutrakul, Vichai,Phanyachotipun, Chitchanun,Turongsomboon, Gunniga,Prapansiri, Vichukorn,Bandara, B. M. R.
, p. 163 - 166 (2007/10/02)
The reactions of lithio α-chloromethyl and α,α-dichloromethyl phenyl sulfoxides with enones gave 1,2 and 1,4 adducts respectively.The reaction of the latter carbanion with enones provides a useful synthesis of novel substituted cyclopropanes.
A NOVEL SYNTHESIS OF α,β-UNSATURATED γ-HYDROXY CARBONYL COMPOUNDS FROM ENONES WITH CARBON HOMOLOGATION
Satoh, Tsuyoshi,Motohashi, Shigeyasu,Yamakawa, Koji
, p. 2889 - 2892 (2007/10/02)
The alkylation of enone with 1-chloroalkyl phenyl sulfoxide followed by treatment with thiophenolate afforded α-phenylthio-β,γ-unsaturated carbonyl compound, which was oxidized and then hydrolyzed to give α,β-unsaturated γ-hydroxy carbonyl compound in good yield.
