1210049-20-9Relevant academic research and scientific papers
N-heterocyclic carbene catalyzed nucleophilic acylation of trifluoromethyl ketimines
Enders, Diester,Henseler, Alexander,Lowins, Sebastian
experimental part, p. 4125 - 4128 (2011/02/28)
An efficient N-heterocyclic carbene (NHC)-catalyzed nucleophilic acylation of trifluoromethyl ketimines has been developed. The combination of N-aryl trifluoromethyl ketimines with various furan-2-carbaldehydes leads chemoselectively to the corresponding α-amino-α-trifluoromethyl ketones in moderate to very good yields (32-87%) providing ready access to this pharmaceutically important class of compounds. Georg Thieme Verlag Stuttgart - New York.
