1210051-75-4Relevant academic research and scientific papers
Synthesis, characterization, and biological activity of substituted thiazole-5-carboxaldehydes and their ylidenenitriles derivatives
Thumar, Nilesh J.,Patel, Manish P.
experimental part, p. 2720 - 2732 (2010/04/05)
The Vilsmeier-Haack reaction of 2-amino -4-(4-substituted phenyl)-thiazoles 1, in the presence of micellar media, gives formylated derivatives 2, which upon hydrolysis afforded thiazole-5-carboxaldehydes 3. Microwave-assisted Knoevenagel condensation of 3 with active methylene compounds, in the presence of piperidine as catalyst, gives excellent yields of ylidenenitrile compounds 4. The structures of the newly synthesized compounds were established on the basis of elemental analysis, IR, 1H NMR, and 13C NMR spectral analysis. All newly synthesized compounds were screened for antibacterial activity using two Gram-positive and one Gram-negative bacterial species and their antifungal activity was screened using two fungal species. Taylor & Francis Group, LLC.
