121010-58-0

Basic information

• Product Name: [(1R,2S,3S,4R,5S,6R)-3,4-dihydroxy-2,5,6-triphosphonooxy-cyclohexyl]oxyphosphonic acid
• Synonyms: [(1R,2S,3S,4R,5S,6R)-3,4-dihydroxy-2,5,6-triphosphonooxy-cyclohexyl]oxyphosphonic acid;1D-myo-Inositol 1,4,5,6-tetrakisphosphate;inositol-1,4,5,6-tetrakisphosphate;Myo-inositol, 1,4,5,6-tetrakis(dihydrogen phosphate);Myo-inositol-1,4,5,6-tetrakisphosphate
• CAS NO: 121010-58-0
• Molecular Formula: C₆H₁₆O₁₈P₄
• Molecular Weight: 500.08
• Product Categories: Carbohydrates & Derivatives;Inositols;Phosphorylating and Phosphitylating Agents;Carbohydrates & Derivatives, Inositols, Phosphorylating and Phosphitylating Agents
• Mol File: 121010-58-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 978.1°Cat760mmHg
• Flash Point: 545.3°C
• Appearance: /
• Density: 2.32g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: [(1R,2S,3S,4R,5S,6R)-3,4-dihydroxy-2,5,6-triphosphonooxy-cyclohexyl]oxyphosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,2S,3S,4R,5S,6R)-3,4-dihydroxy-2,5,6-triphosphonooxy-cyclohexyl]oxyphosphonic acid(121010-58-0)
• EPA Substance Registry System: [(1R,2S,3S,4R,5S,6R)-3,4-dihydroxy-2,5,6-triphosphonooxy-cyclohexyl]oxyphosphonic acid(121010-58-0)

Safety Data

• Hazardous Substances Data: 121010-58-0(Hazardous Substances Data)

Usage

Uses

Ins(1,4,5,6)P4, a biol. active cell constituent, was recently advocated as a substrate of human Ins(3,4,5,6)P4 1-kinase (hITPK1), because stereochemistry factors were believed relatively unimportant to specificity. Ins(1,4,5,6)P4 is phosphorylated by inositol-phosphate-multikinase but not human ITPK1.

InChI:InChI=1/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m1/s1

Upstream product

• 114488-20-9 myo-Inositol 1,5,6-trisphosphate 
• 181782-84-3 D-2,3-Di-O-butyryl-myo-inositol 
• 57029-87-5 (±)-1,2-cyclohexylidene myo-inositol 
• 80582-74-7 (1S,2S,3S,4S)-anti-benzene dioxide 
• 163580-32-3 D-2,3-Di-O-butyryl-myo-inositol 1,4,5,6-tetrakisphosphate 
• 157542-48-8 D-2,3-O-cyclohexylidene-1,4,5,6-tetra-O-(bisbenzyloxyphosphoryl)-myo-inositol 

Downstream Products

• 26326-86-3 Ins(1,2,3,4,5)P₅ 
• 114488-20-9 myo-Inositol 1,5,6-trisphosphate 

Relevant articles and documents

Regulation of ins(3456)p4 signalling by a reversible kinase phosphatase and methods and compositions related thereto

Provided is a method of increasing 3,4,5,6-tetrakisphosphate by increasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase, and a method of decreasing 3,4,5,6-tetrakisphosphate by decreasing the activity of inositol 1,3,4,5,6 pentakisph

A Definitive Synthesis of D-myo-Inositol 1,4,5,6-Tetrakisphosphate and Its Enantiomer D-myo-Inositol 3,4,5,6-Tetrakisphosphate from a Novel Butane-2,3-diacetal-Protected Inositol

New and rapid syntheses of the enantiomeric intracellular signalling molecules D-myo-inositol 1,4,5,6-tetrakisphosphate (1a) and D-myo-inositol 3,4,5,6-tetrakisphosphate (1b) are described. The synthetic strategy employs the novel butane-2,3-diacetal-prot

Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3,4,5-trisphosphate and D-myo-inositol 1,5,6-trisphosphate: Aspects of their structure-activity relationship to biologically active inositol phosphates

Unambiguous total syntheses of both optical antipodes of the enantiomeric pair D-myo-inositol 3,4,5-trisphosphate (Ins(3,4,5)P3) and D- myo-inositol 1,5,6-trisphosphate (Ins(1,5,6)P3) are described. The ring system characteristic of