121014-53-7

Basic information

• Product Name: BIG ET-1 (1-38) (HUMAN)
• Synonyms: ENDOTHELIN, BIG 38;Big endothelin 1(1-38);Cys(1)-Ser-Cys(2)-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys(2)-Val-Tyr-Phe-Cys(1)-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH;Big Endothelin-1 (huMan) Big ET-1 (1-38) (huMan);H-CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-ARG-SER-OH;CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-ARG-SER;CSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRS;CSCSSLMDKECVYFCHLDIIWVNIPEHWPYGLGSPRS
• CAS NO: 121014-53-7
• Molecular Formula: C189H287N49O55S5
• Molecular Weight: 4285.92138
• Product Categories: Peptide;Cardiovescular;proteins
• Mol File: 121014-53-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: BIG ET-1 (1-38) (HUMAN)(CAS DataBase Reference)
• NIST Chemistry Reference: BIG ET-1 (1-38) (HUMAN)(121014-53-7)
• EPA Substance Registry System: BIG ET-1 (1-38) (HUMAN)(121014-53-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 121014-53-7(Hazardous Substances Data)

Usage

General Description

BIG ET-1 (1-38) (HUMAN) is a peptide hormone that belongs to the endothelin protein family. It is a precursor molecule of endothelin-1, a vasoconstrictive peptide that plays a significant role in the regulation of blood pressure and vascular tone. The "BIG" in its name stands for "big endothelin" and refers to the larger molecular size of the peptide before it is processed into the biologically active form. This precursor form is cleaved to produce endothelin-1, which binds to endothelin receptors in the vascular smooth muscle cells, leading to vasoconstriction. The peptide is produced in various tissues, including the endothelium, and plays a role in physiological processes such as the regulation of blood flow and maintaining cardiovascular homeostasis. Dysregulation of endothelin-1 has been implicated in various cardiovascular diseases, making it an important target for therapeutic interventions.