121045-35-0Relevant academic research and scientific papers
Visible light-induced monofluoromethylenation of heteroarenes with ethyl bromofluoroacetate
Yu, Wei,Xu, Xiu-Hua,Qing, Feng-Ling
, p. 6564 - 6567 (2016/08/09)
Visible light-induced monofluoromethylenation of benzofurans and benzothiophenes with ethyl bromofluoroacetate was developed. This method provided a convenient access to novel α-fluoro-α-heteroarylesters under mild reaction conditions.
S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF
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Page/Page column 57; 75, (2008/06/13)
The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
SELECTIVE PREPARATION AND CYCLIZATION OF 2-(2-HYDROXYPHENYL)-2-(ISOPROPYLTHIO)ETHANOLS. NEW SYNTHESIS OF 1-BENZOFURANS
Ota, Tomomi,Hasegawa, Shun,Inoue, Seiichi,Sato, Kikumasa
, p. 3029 - 3036 (2007/10/02)
Reaction of phenols with 2-(isopropylthio)ethyl acetate activated by sulphuryl chloride afforded 2-phenols regioselectively, via sigmatropic rearrangement of phenoxysulphonium ylides.The ortho-alkylated phenols thus obtained have been cyclized with conc. hydrochloric acid in 2-methoxyethanol to 1-benzofurans. 2-Methyl- and 2-phenyl-1-benzofurans have been prepared similarly.
