121045-63-4

Upstream product

• 100-44-7 benzyl chloride 
• 121045-59-8 2-<<2-(ethoxycarbonyl)-1H-pyrrol-4-yl>methyl>benzoic acid 
• 85-44-9 phthalic anhydride 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 

Downstream Products

• 121045-62-3 2-<(1-benzyl-5-ethoxycarbonylpyrrol-3-yl)methyl>benzoic acid 
• 121045-64-5 ethyl 1-benzyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate 
• 121045-66-7 ethyl 1-benzyl-9-methoxy-1H-benzindole-2-carboxylate 
• 121045-65-6 ethyl 1-benzyl-4,9-dioxo-4,9-dihydro-1H-benzindole-2-carboxylate 

Relevant academic research and scientific papers

SYNTHESIS OF LINEAR ETHYL 9-METHOXY-1H-BENZINDOLE-2-CARBOXYLATE

This paper describes a synthesis of genuine ethyl 9-methoxy-1H-benzindole-2-carboxylate (6).The genuine synthetic specimen has different physical properties from those of the indole reported as ethyl 9-methoxy-1H-benzindole-2-carboxylate, which was obtained by Fischer indolisation of ethyl pyruvate 2-(1-methoxy-2-naphthylhydrazone) (9) by Goldsmith and Lindwall. Our synthetic method includes the Fridel-Crafts acylation of ethyl pyrrole-2-carboxylate (13) with phthalic anhydride and a new selective N-debenzylation of N-benzylindole derivatives having a methoxy group in their molecule with aluminium chloride in anisole at room temperature.