121050-01-9Relevant academic research and scientific papers
Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake
Ding, Derong,Nickell, Justin R.,Deaciuc, Agripina G.,Penthala, Narsimha Reddy,Dwoskin, Linda P.,Crooks, Peter A.
, p. 6771 - 6777 (2013)
Lobelane analogs that incorporate a central piperidine or pyrrolidine moiety have previously been reported by our group as potent inhibitors of VMAT2 function. Further central ring size reduction of the piperidine moiety in lobelane to a four-membered het
METHOD OF TREATMENT WITH 3-CYCLOPROPYLCARBONYL-3,6-DIAZABICYCLO[3.1.1]HEPTANE
-
, (2014/02/15)
The present invention relates to 3-cyclopropylcarbonyl-3,6-diazabicyclo[3.1.1]heptane, its salt forms, pharmaceutical compositions, and methods of treatment thereof.
SALT FORMS OF 3 - CYCLOPROPYLCARBONYL - 3, 6 - DIAZABICYCLO [3.1.1] HEPTANE
-
, (2012/10/07)
The present invention relates to 3-cyclopropylcarbonyl-3,6-diazabicyclo[3.1.1]heptane, its salt forms, and novel polymorphic forms of these salts.
Azetidine derivatives to treat memory and learning disorders
-
, (2008/06/13)
This invention relates to novel azetidines and derivatives thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and composi
Synthesis and Bioactivity of a New Class of Rigid Glutamate Analogues. Modulators of the N-Methyl-D-aspartate Receptor
Kozikowski, Alan P.,Tueckmantel, Werner,Reynolds, Ian J.,Wroblewski, Jarda T.
, p. 1561 - 1571 (2007/10/02)
A variety of derivatives of azetidine-2,4-dicarboxylic acid were synthesized and examined for their ability to stimulate 45Ca2+ uptake in cultures of cerebellar granule cells.Of the compounds tested, the cis-azetidine-2,4-dicarboxylic acid (10f
Azetidine derivatives, compositions and methods of treating
-
, (2008/06/13)
This invention relates to novel azetidines and derivative thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and compositions as biological tools and materials for characterizing excitatory amino acid receptor systems. A further aspect of the invention relates to a method of treating PCP toxicity and abuse.
