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Product FOB Price Min.Order Supply Ability Supplier
MelanotanII CAS 121062-08-6 MT2
Cas No: 121062-08-6
USD $ 10.0-10.0 / Gram 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
Melanotan II Mt2 Skin Tanning Powder Polypeptides Melanotan 2
Cas No: 121062-08-6
No Data 100 Gram 1 Metric Ton/Month Shanghai CRM New Material Technology Co., LTD Contact Supplier
MT2/Melanotan-II
Cas No: 121062-08-6
USD $ 1.0-1.0 / Gram 1 Gram 100 Metric Ton/Day shanghai Longyu biotechnology Co.,Ltd Contact Supplier
High quality Melanotan-2/MT2/MT-II Melanotan2 powder,melanotan ii,Melanotan-II CAS NO.121062-08-6
Cas No: 121062-08-6
USD $ 50.0-55.0 / box 1 box 10000 box/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Melanotan 2 /MT2 /MT II CAS 121062-08-6
Cas No: 121062-08-6
USD $ 45.0-50.0 / box 1 box 1 Kilogram/Day Hubei Vanz Pharm Co.,Ltd Contact Supplier
Melanotan 2,MT-2 10mg/vial With Safe Delivery
Cas No: 121062-08-6
No Data 1 box 1 Metric Ton/Day Wuhan Godbullraw Chemical Co.,ltd Contact Supplier
Best price/ Melanotan II
Cas No: 121062-08-6
No Data 1 Kilogram 100 Metric Ton/Year Jilin haofei import and export trade Co.,Ltd Contact Supplier
Melanotan II/ Melanotan 2/MT2/121062-08-6
Cas No: 121062-08-6
No Data 10 Gram 3 Metric Ton/Week Qingdao Beluga Import and Export Co., LTD Contact Supplier
Hot Sale peg-mgf peptide CAS 121062-08-6 Lyophilized Bodybuilding Peptide pegmgf
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USD $ 50.0-100.0 / Gram 1 Gram 30000 Metric Ton/Day Hebei Ruiyao Biological Technology Co., Ltd. Contact Supplier
Peptides Melanotan II Acetate MelanotanII Acetate MT-2
Cas No: 121062-08-6
USD $ 1.0-1.0 / Milligram 1 Milligram 100 Kilogram/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier

121062-08-6 Usage

Description

Melanotan II is a synthetic analogue of the melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that occurs naturally. In usage, Melanotan II has been revealed to have aphrodisiac and melanogenesis (tanning) effects that have been subjected to clinical trials and preliminary studies. The compound is a cyclic lactam analogue of α-MSH that has an amino sequence named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2). Notably, no government drug regulatory agency across the world had approved for the use of any compound incorporating the Melanotan II peptide by 2010

Uses

Malanotan II is used for tanning of the skin and producing of erections in men with erectile dysfunction when administered as a shot under the skin. Malanotan II is safe when used under strict medical supervision for treating erectile dysfunction. However, it may cause stomach cramps, tiredness, nausea, spontaneous erections of the penis, and darkened skin.

Clinical Use

Melanotan II has been a new treatment for rosacea discussed in the various rosacea support groups on the internet. Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Melanotan II has the additional effect of increasing libido. Melanotan II is an α-MSH analog which underwent clinical trials for the treatment of erectile dysfunction. Preliminary double-blind, placebo-controlled studies demonstrated the efficacy of melanotan in inducing penile erection in men with erectile dysfunction, although in a very restricted population.Unfortunately, there are no experimental data on the mode of action of melanotan II, as melanotan II is the first α-MSH agonist inducing penile erection when injected peripherally. Illustration of the proerectile effect of melanotan II (MT-II) in humans. Placebo (A) or MT-II (B, 25 ug/kg and C, 133 ug/kg) was injected subcutaneously in patients and RigiScan recording was performed from 6 h. Apparent erections developed in 8 of 10 men treated with MT-II. (Reproduced with permission from Wessells H et al. Effect of an alphamelanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 2000; 56:641–646.)

Historical Development

Melanotan II was first developed at the University of Arizona. Various studies conducted at the institution confirmed that the best defence against skin cancer was melanin activated in the skin, a tan. The researchers assumed that an effective procedure to reduce the rates of skin cancer in individuals would be by inducing the body’s natural pigmentary system to produce a tan that would be protective before exposure to UV. Melanogenesis is a process by which the skin’s pigment cells (melanocytes) produce the hormone α-MSH naturally causes the skin's pigment (melanin). After numerous clinical trials by administration of the endogenous hormone to the body, the scientists found that though it appeared to work, α-MSH had a very short half-life in the body to be practical as a therapeutic drug. Therefore, they opted to look for a more stable and potent alternative that would be more practical. Subsequently, after numerous trials, they developed Melanotan I and after that Melanotan II.

Controversy

Melanotan II is widely sold online and in beauty salons as well as gyms as melanotan in their marketing. These products purport to contain the same chemical composition as afamelanotide. These products have been declared illegal and do not have the same chemical components as Melanotan II. As such, countries issues warnings against their use.
InChI:InChI=1/C50H71N15O10/c1-3-4-16-36(59-29(2)66)44(70)65-41(25-42(67)68)49(75)64-40(24-32-27-55-28-58-32)48(74)62-38(22-30-13-6-5-7-14-30)46(72)61-37(19-12-21-56-50(53)54)45(71)63-39(23-31-26-57-34-17-9-8-15-33(31)34)47(73)60-35(43(52)69)18-10-11-20-51/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25,51H2,1-2H3,(H2,52,69)(H,55,58)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,67,68)(H4,53,54,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1

121062-08-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Melanotan II acetate salt

1.2 Other means of identification

Product number -
Other names (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:121062-08-6 SDS

121062-08-6Synthetic route

melanotan-II
121062-08-6

melanotan-II

Boc-Arg(Tos)-OH
13836-37-8

Boc-Arg(Tos)-OH

Boc-Lys(Fmoc)-OH
84624-27-1

Boc-Lys(Fmoc)-OH

Boc-D-Phe-OH
18942-49-9

Boc-D-Phe-OH

Nα-tert-butoxycarbonyl-1-formyl-L-tryptophan
47355-10-2

Nα-tert-butoxycarbonyl-1-formyl-L-tryptophan

Nα-Boc-His(Nϖ-Bom), Nα-Boc-Asp(β-Fmo), Nα-Boc-Nle, Ac2O

Nα-Boc-His(Nϖ-Bom), Nα-Boc-Asp(β-Fmo), Nα-Boc-Nle, Ac2O

melanotan-II
121062-08-6

melanotan-II

Conditions
ConditionsYield
Yield given. Multistep reaction;
Boc-Arg(Tos)-OH
13836-37-8

Boc-Arg(Tos)-OH

Boc-Lys(Fmoc)-OH
84624-27-1

Boc-Lys(Fmoc)-OH

Boc-D-Phe-OH
18942-49-9

Boc-D-Phe-OH

Nα-Boc-Trp (Nin-MeS)
92916-47-7

Nα-Boc-Trp (Nin-MeS)

Nα-Boc-His (Nϖ-Bom), Nα-Boc-Asp (β-OFm), Nα-Boc-Nle, Ac2O

Nα-Boc-His (Nϖ-Bom), Nα-Boc-Asp (β-OFm), Nα-Boc-Nle, Ac2O

melanotan-II
121062-08-6

melanotan-II

Conditions
ConditionsYield
Multistep reaction;
Fmoc-Asp(ODmab)-OH; Dmab = 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl
269066-08-2

Fmoc-Asp(ODmab)-OH; Dmab = 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl

acetic anhydride
108-24-7

acetic anhydride

Fmoc-D-Phe-OH
86123-10-6

Fmoc-D-Phe-OH

Fmoc-His(Trt)-OH
109425-51-6

Fmoc-His(Trt)-OH

Fmoc-(S)-2-aminohexanoic acid
77284-32-3

Fmoc-(S)-2-aminohexanoic acid

Fmoc-Lys(Dde)-OH
150629-67-7

Fmoc-Lys(Dde)-OH

3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester
143824-78-6

3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

melanotan-II
121062-08-6

melanotan-II

Conditions
ConditionsYield
Stage #1: Fmoc-Lys(Dde)-OH With 4-methyl-morpholine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide for 0.666667h;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.416667h;
Stage #3: Fmoc-Asp(ODmab)-OH; Dmab = 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl; acetic anhydride; Fmoc-D-Phe-OH; Fmoc-His(Trt)-OH; Fmoc-(S)-2-aminohexanoic acid; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;
C94H103N14O14PolS

C94H103N14O14PolS

acetic anhydride
108-24-7

acetic anhydride

Fmoc-(S)-2-aminohexanoic acid
77284-32-3

Fmoc-(S)-2-aminohexanoic acid

melanotan-II
121062-08-6

melanotan-II

Conditions
ConditionsYield
Stage #1: C94H103N14O14PolS With piperidine; benzotriazol-1-ol In dichloromethane; N,N-dimethyl-d6-formamide at 20 - 75℃; for 0.1h; rink-amide-MBHA resin; Microwave irradiation;
Stage #2: Fmoc-(S)-2-aminohexanoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 75℃; for 0.0833333h; rink-amide-MBHA resin; Microwave irradiation;
Stage #3: acetic anhydride Further stages;
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