121063-30-7Relevant academic research and scientific papers
Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues
Sugimori, Masamichi,Ejima, Akio,Ohsuki, Satoru,Uoto, Kouichi,Mitsui, Ikuo,Kawato, Yasuyoshi,Hirota, Yasuhide,Sato, Keiki,Terasawa, Hirofumi
, p. 2308 - 2318 (2007/10/03)
Nineteen ring A- and F-modified hexacyclic analogues of camptothecin were synthesized by Friedlander condensation of appropriately substituted bicyclic amino ketones with tricyclic ketone and were evaluated for cytotoxicity and topoisomerase I inhibitory
Hexa-cyclic camptothecin derivatives
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, (2008/06/13)
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: STR1 The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumor activity and a high
