121067-62-7

Basic information

• Product Name: Methylthioninium Chloride
• Synonyms: C.I. 52015; C.I. Basic Blue 9; Basic Blue 9; Methylene blue; 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride; Basic Blue 9; CI 52015; Methylene Blue anhydrous; Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride; 3,7-Bis(dimethylamino)phenazathionium chloride; Aizen Methylene Blue BH; Aizen Methylene Blue FZ; Bleu de methylene; CCRIS 833; CI Basic Blue 9; Calcozine Blue ZF; Caswell No. 567; Ceruleum methylenum; Chlorure de methylthioninium; Chlorure de methylthioninium [INN-French]; Chromosmon; Cloruro de metiltioninio; Cloruro de metiltioninio [INN-Spanish]; D And C Blue Number 1; D and C Blue No. 1; EINECS 200-515-2; EPA Pesticide Chemical Code 039505; Ext D and C Blue No. 1; External Blue 1; HSDB 1405; Hidaco Methylene Blue Salt Free; Leather Pure Blue HB; M-B Tabs; Methylenblau; Methylenblau [German]; Methylene Blue (medicinal); Methylene Blue 2B; Methylene Blue 2BF; Methylene Blue 2BN; Methylene Blue 2BP; Methylene Blue A; Methylene Blue B; Methylene Blue BB; Methylene Blue BB (zinc free); Methylene
• CAS NO: 121067-62-7
• Molecular Formula: C₁₆H₁₈ClN₃S
• Molecular Weight: 319.8522
• EINECS: 200-515-2
• Mol File: 121067-62-7.mol
• Article Data: 41

Chemical Properties

• Water Solubility: 40 g/L (20℃)
• CAS DataBase Reference: Methylthioninium Chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methylthioninium Chloride(121067-62-7)
• EPA Substance Registry System: Methylthioninium Chloride(121067-62-7)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:; R41:
• Safety Statements: S26:; S39:
• Hazardous Substances Data: 121067-62-7(Hazardous Substances Data)

Upstream product

• 531-53-3 azure A 
• 99-98-9 4-amino-N,N-dimethylaniline 
• 15967-15-4 (4-(2-(thiosulfate)-4-(dimethylamino)-phenylimino)-cyclohex-2,5-dienylidene)-N,N-dimethyl ammonium 
• 71802-09-0 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide 
• 92-84-2 10H-phenothiazine 
• 124-40-3 dimethyl amine 
• 536-46-9 4-dimethylaminophenylamine dihydrochloride 
• 1249-97-4 [3,7-bis(dimethylamino)phenothiazin-10-yl]phenylmethanone 
• 536-47-0 N,N-dimethyl-1,4-phenylenediamine sulfate 
• 50-00-0 formaldehyd 
• 1747-90-6 3,11-dinitro-10H-phenothiazine 
• 121-69-7 N,N-dimethyl-aniline 
• 4727-46-2 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide 

Downstream Products

• 115871-18-6 sodium salt of 10-(carboxymethylaminocarbonyl)-3,7-bis(dimethylamino)phenothiazine 
• 13760-29-7 tetrathionic acid 
• 531-53-3 azure A 
• 531-55-5 azure B 
• 531-57-7 Azure C 
• 100-61-8 N-methylaniline 
• 106-50-3 1,4-phenylenediamine 
• 124-38-9 carbon dioxide 
• 7732-18-5 water 
• 95-54-5 1,2-diamino-benzene 
• 98-11-3 benzenesulfonic acid 
• 108-95-2 phenol 
• 108-88-3 toluene 
• 61-54-1 tryptamine 

Relevant articles and documents

AND molecular logic gates based on host-guest complexation operational in live cells

We report supramolecular AND logic gates based on host-guest complexation between acid-labile acyclic cucurbit[n]uril (CB[n]) molecular container and NaClO-responsive dye. Supramolecular AND logic gate is turned on due to acid-triggered degradation of mol

A PROCESS FOR THE PREPARATION OF METHYLENE BLUE

Provided herein is a process for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride: Formula (I). The said process comprises preparing 3,7-dibromophenothiazin-5-ium bromide wet Crude(III) from phenothiazine (II) along promoter, catalyst and brominating agent in presence of organic solvent; preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide (IV) from 3,7-dibromophenothiazin-5-ium bromide; preparing 3,7-bis (Dimethylamino)-phenothiazin-5-ium chloride from 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide and subsequently purifying and removing metal content through metal scavenger from 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (I). The present process eliminates the additional step of ion exchange column in the reaction and provides 99 to 99.5 percentage of product purity.

METHOD FOR PREPARING 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-YLIUM IODIDE

Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the method resulting in a high purity while being very simple to implement and producing high yields. The method uses phenothiazine as a starting material and includes the following steps: a) treating phenothiazine with diiodine, b) treating the reaction medium directly obtained from step a) with dimethylamine.