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121069-00-9

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121069-00-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 121069-00-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,0,6 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 121069-00:
(8*1)+(7*2)+(6*1)+(5*0)+(4*6)+(3*9)+(2*0)+(1*0)=79
79 % 10 = 9
So 121069-00-9 is a valid CAS Registry Number.

121069-00-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-dichloro-1-(4-ethylphenyl)ethanone

1.2 Other means of identification

Product number -
Other names Ethanone,2,2-dichloro-1-(4-ethylphenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:121069-00-9 SDS

121069-00-9Downstream Products

121069-00-9Relevant articles and documents

Electrochemical synthesis of α,α-dihaloacetophenones from terminal alkyne derivatives

Li, Zhibin,Sun, Qi,Qian, Peng,Hu, Kangfei,Zha, Zhenggen,Wang, Zhiyong

, p. 1855 - 1858 (2020)

By virtue of electrochemistry, a series of α,α-dihaloacetophenones were easily obtained with good to excellent yields. This electrochemical procedure was taken in a divided cell with constant current in aqueous media. The reaction can be carried out smoothly at room temperature under metal and oxidant free condition, which provides an eco-friendly synthesis for the α,α-dihaloacetophenone derivatives.

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Zhang, Shao-Lin,Yang, Zheng,Hu, Xiaohui,Tam, Kin Yip

supporting information, p. 3441 - 3445 (2018/09/29)

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.

Halogenation Using Quaternary Ammonium Polyhalides. XXXII. Dichlorination of Aromatic Acetyl Derivatives with Benzyltrimethylammonium Tetrachloroiodate

Kakinami, Takaaki,Urabe, Yasuaki,Hermawan, Irwan,Yamanishi, Hiroko,Okamoto, Tsuyoshi,Kajigaeshi, Shoji

, p. 2549 - 2551 (2007/10/02)

The reaction of aromatic acetyl derivatives with 2 molar amounts of benzyltrimethylammonium tetrachloroiodate in acetic acid at 70 deg C for several hours gave dichloroacetyl derivatives in good yields.

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