1210802-46-2Relevant academic research and scientific papers
Total synthesis of chloptosin, a potent apoptosis-lnducing cyclopeptide
Yu, Shun-Ming,Hong, Wen-Xu,Wu, Yuan,Zhong, Chun-Long,Yao, Zhu-Jun
, p. 1124 - 1127 (2010)
Chemical Equation Presentation A bidirectional total synthesis of chloptosin has been achieved in 16 operations (32 individual reactions) and 3% overall yield from the readily available materials. Palladium-catalyzed tryptophan synthesis, diastereoselective selenocyclization and oxidative deselenation successfully served as key steps In construction of the dimeric core amino acid. 2-Bromo-1-ethyl pyridinium tetrafluoroborate was efficiently employed In the peptide couplings with spatial encumbrance In this synthesis.
