1210812-73-9

Basic information

• Product Name: 4,5-dibromo-2-[(4-methoxyphenyl)methyl]-2,3-dihydropyridazin-3-one
• Synonyms: 4,5-dibromo-2-[(4-methoxyphenyl)methyl]-2,3-dihydropyridazin-3-one
• CAS NO: 1210812-73-9
• Molecular Weight: 374.032
• Mol File: 1210812-73-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4,5-dibromo-2-[(4-methoxyphenyl)methyl]-2,3-dihydropyridazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dibromo-2-[(4-methoxyphenyl)methyl]-2,3-dihydropyridazin-3-one(1210812-73-9)
• EPA Substance Registry System: 4,5-dibromo-2-[(4-methoxyphenyl)methyl]-2,3-dihydropyridazin-3-one(1210812-73-9)

Safety Data

• Hazardous Substances Data: 1210812-73-9(Hazardous Substances Data)

Upstream product

• 5788-58-9 4,5-dibromo-3(2H)pyridazinone 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1210812-75-1 2-(4-methoxybenzyl)-5-bromo-4-(methylamino)pyridazin-3(2H)-one 
• 1240496-71-2 2-(4-methoxybenzyl)-4-bromo-5-(methylamino)pyridazin-3(2H)-one 

Relevant articles and documents

PYRIDAZINONES AS PARP7 INHIBITORS

The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.

1 -((6-OXO-1,6-DIHYDROPYRIDAZIN-4-YL)METHYL)PIPERAZINE AND 1 -((6-OXO-1,6-DIHYDROPYRIMIDIN-4-YL)METHYL)PIPERAZINE DERIVATIVES AS PROLYL HYDROXYLASE, HIF-1 ALPHA AND PGK MODULATORS FOR USE IN TREATING INFLAMMATORY DISEASES, CANCER OR INFECTIONS

Described herein are compounds of formulae (I), (lla) and (Mb) as prolyl hydroxylase inhibitors, HIF-lalpha stabilizers and PGK up regulators for use in treating inflammatory diseases, cancer or infections: Preferred compounds are e.g. tert-butyl-4-((l-benzyl-6-oxo-l,6- dihydropyridazin-4-yl)methyl)piperazine-l-carboxylate and tert-butyl-4-((l-benzyl-6-oxo-l,6-dihydropyrimidin-4-y I) methyl) piperazine-l-carboxylate derivatives and related compounds. Exemplary compounds are e.g. compound 1A: and compound 2A: The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 22 to 25 and 55 to 70; examples 1 to 5; compounds 1A to 2V; tables 1 and 2).

PYRIDAZINONES AS PARP7 INHIBITORS

The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.