1210828-44-6

Basic information

• Product Name: 7-Quinolinol, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-
• Synonyms: 7-Quinolinol, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-;4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-ol
• CAS NO: 1210828-44-6
• Molecular Formula: C19H15FN2O3
• Molecular Weight: 338.3324032
• Mol File: 1210828-44-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Quinolinol, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Quinolinol, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-(1210828-44-6)
• EPA Substance Registry System: 7-Quinolinol, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-(1210828-44-6)

Safety Data

• Hazardous Substances Data: 1210828-44-6(Hazardous Substances Data)

Usage

General Description

7-Quinolinol, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy- is a complex chemical compound with a molecular formula C21H16FN3O3. It is comprised of a quinolinol core with a 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy- substituent, making it a derivative of both quinolinol and indole. This chemical is utilized in various research and industrial applications, including as a building block in the synthesis of pharmaceutical compounds and as a fluorescence label for biochemical assays. Additionally, it exhibits potential pharmaceutical properties, particularly in the areas of antiviral and antiparasitic activity. However, further research and testing are required to fully understand and harness the potential of this compound.

Upstream product

• 1210828-43-5 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-benzyloxyquinoline 
• 288385-88-6 4-fluoro-2-methyl-1H-indol-5-ol 
• 1210828-42-4 1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one 
• 649736-31-2 1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one 
• 286371-49-1 7-(benzyloxy)-4-chloro-6-methoxyquinoline 
• 205448-29-9 7-benzyloxy-4-hydroxy-6-methoxyquinoline 

Downstream Products

• 1058156-90-3 1?[[[4?(4?fluoro?2?methyl?1H?indole?5?yl)oxy?6?methoxyquinoline?7?yl]oxy]methyl]cyclopropylamine 

Relevant articles and documents

Angiogenesis inhibitor as well as preparation method and application thereof

The invention belongs to the technical field of medicines, and discloses a compound shown as a formula I or pharmaceutically acceptable salt, prodrug, metabolite, isotope derivative and solvate thereof. The compound provided by the invention is a cyclobutyl-containing compound used as a tyrosine kinase inhibitor, and can be used for treating tyrosine kinase, especially tumor diseases related to VEGFR. Due to the existence of the cyclobutyl group, the rigidity of a branched chain molecule can be improved, the directivity of the molecule is improved, the compound can be better combined with a target easily, the dosage of a drug can be reduced, and the side effect of the drug is reduced. The invention also provides a preparation method of the compound and application of the compound in treatment of tumor diseases caused by abnormal activity of tyrosine kinase such as VEGFR.

Method for preparing anlotinib hydrochloride

The invention discloses a method for preparing anlotinib hydrochloride. The method has the advantages that 7-benzyloxy-4-chlorine-6-methoxyquinoline compounds 1 and 1-(2-fluorine-3-hydroxyl-6-nitrophenyl) propyl-2-ketone compounds 2 are used as starting m

Compounds As Kinase Inhibitors

The present invention relates to compounds of Formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with angiogenesis, such as cancers associated with protein tyrosine kinases, to their use as medicaments for use in the production of inhibition of tyrosine kinases reducing effects in warm-blooded animals such as humans.