121083-05-4 Usage
Uses
L-670,596 is a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
Biological Activity
Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist (IC 50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA 2 = 9.0) and human platelet aggregation in vitro (IC 50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 121083-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,0,8 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 121083-05:
(8*1)+(7*2)+(6*1)+(5*0)+(4*8)+(3*3)+(2*0)+(1*5)=74
74 % 10 = 4
So 121083-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H21F2NO4S/c1-30(28,29)16-7-5-13(6-8-16)12-25-21-14(9-20(26)27)3-2-4-17(21)18-10-15(23)11-19(24)22(18)25/h5-8,10-11,14H,2-4,9,12H2,1H3,(H,26,27)
121083-05-4Relevant articles and documents
Tetrahydrocarbazole esters, pharmaceutical compositions and use
-
, (2008/06/13)
Tetrahydrocarbazole esters are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
Tetrahydrocarbazoles for the improvement of cyclosporin therapy
-
, (2008/06/13)
Tetrahydrocarbazoles, especially Tetrahydrocarbazole-1-alkanoic acids are disclosed. The compounds are useful for improving cyclosporine therapy. In particular, the compounds are useful for limiting cyclosporine induced nephrotoxicity which comprises the
