1210908-67-0

Basic information

• Product Name: METHYL 5-CHLORO-2-([(E)-4,4,4-TRIFLUORO-1-METHYL-3-OXO-1-BUTENYL]AMINO)BENZENECARBOXYLATE
• Synonyms: METHYL 5-CHLORO-2-([(E)-4,4,4-TRIFLUORO-1-METHYL-3-OXO-1-BUTENYL]AMINO)BENZENECARBOXYLATE;Benzoic acid, 5-chloro-2-[[(1E)-4,4,4-trifluoro-1-methyl-3-oxo-1-buten-1-yl]amino]-, methyl ester
• CAS NO: 1210908-67-0
• Molecular Formula: C₁₃H₁₁ClF₃NO₃
• Molecular Weight: 321.68
• Mol File: 1210908-67-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL 5-CHLORO-2-([(E)-4,4,4-TRIFLUORO-1-METHYL-3-OXO-1-BUTENYL]AMINO)BENZENECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-CHLORO-2-([(E)-4,4,4-TRIFLUORO-1-METHYL-3-OXO-1-BUTENYL]AMINO)BENZENECARBOXYLATE(1210908-67-0)
• EPA Substance Registry System: METHYL 5-CHLORO-2-([(E)-4,4,4-TRIFLUORO-1-METHYL-3-OXO-1-BUTENYL]AMINO)BENZENECARBOXYLATE(1210908-67-0)

Safety Data

• Hazardous Substances Data: 1210908-67-0(Hazardous Substances Data)

Upstream product

• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 135351-20-1 1,1,1-trifluoro-4-methoxypent-3-en-2-one 

Downstream Products

• 1210908-77-2 methyl 5-chloro-2-((1E,3E)-1-(dimethylamino)-6,6,6-trifluoro-5-oxohexa-1,3-dien-3-ylamino)benzoate 

Relevant articles and documents

Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors

Fatty acid amide hydrolase (FAAH) is the key hydrolytic enzyme for the endogenous cannabinoid receptor ligand anandamide. The synthesis and evaluation for their FAAH inhibitory activities of a series of 18 paracetamol esters are described. Structure-activity relationship studies indicated that the ester (33) with a 2-(4-(2-(trifluoromethyl)pyridin-4-ylamino)phenyl)acetic acid substituent was the most potent analogue in this series. The compound inhibited FAAH activity in a competitive manner with a Ki value of 0.16 μM. The compound was also able to inhibit the FAAH activity in rat basophilic leukemia cells as assessed by measuring either the hydrolysis of anandamide, the FAAH-dependent cellular accumulation of anandamide, or the FAAH-dependent recycling of tritium to the cell membranes. The compound also inhibited the activity of monoacylglycerol lipase (MGL), the enzyme responsible for the hydrolysis of the endogenous cannabinoid receptor ligand 2-arachidonoylglycerol, with an IC50 value of 1.9 μM. It is concluded that the compound may be a useful template for the design of potent novel inhibitors of FAAH.