121099-07-8Relevant articles and documents
Unexpected Dehydrogenation of a Cyclohexyl Group at Low Temerature through Protonation of RuH3(η5-C5Me5)(PCy3) (Cy = cyclohexyl). X Ray Structure of 5-C5Me5)Ru((C6H9)P(C6H11)2)>BF4
Arliguie, Therese,Chaudret, Bruno,Jalon, Felix,Lahoz, Fernando
, p. 998 - 1000 (1988)
Low temperature protonation of RuH3(η5-C5Me5)(PR3) (R = Pri, Ph, cyclohexyl) leads either to decomposition (R = Pri) to a mixture of cis- and trans-5-C5Me5)(PR3)2>BF4 (R = Ph), or to dehydrogenation of a cyclohexyl group to afford the complex 5-C5Me5)((C6H9)P(C6H11)2)>BF4 which shows a strong agostic interaction beween a C-H bond of the cyclohexyl group and the metal; a possible application of the later observation is proposed for the dehydrogenation of alkenes.
Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade
Wang, Chengpeng,Dong, Guangbin
supporting information, p. 6057 - 6061 (2018/05/14)
We report a direct β-alkylation of ketones and aldehydes with simple alkyl bromides through a Pd-catalyzed redox-cascade strategy. The use of a Cu cocatalyst is important for improved efficiency. The reaction is redox-neutral, without the need for strong acids or bases. Both cyclic and acyclic ketones, as well as α-branched aldehydes, are suitable substrates for coupling with secondary and tertiary alkyl bromides. Concise formal synthesis of Zanapezil is achieved using this β-alkylation method.
