121103-15-9

Basic information

• Product Name: Carbamic acid, [(2S)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(2S)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI);(S)-tert-butyl 2-aminopropylcarbamate;S-1-N-BOC-propane-1,2-diamine-HCl;tert-Butyl N-[(2S)-2-aMinopropyl]carbaMate;(S)-1-N-Boc-Propane-1,2-diaMine hydrochloride;CarbaMic acid, [(2S)-2-aMinopropyl]-, 1,1-diMethylethyl ester;((S)-2-Aminopropyl)carbamic acid tert-butyl ester;N-((S)-2-Aminopropyl)carbamic acid tert-butyl ester
• CAS NO: 121103-15-9
• Molecular Formula: C₈H₁₈N₂O₂
• Molecular Weight: 174.24072
• Product Categories: N-BOC
• Mol File: 121103-15-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 263.7±23.0 °C(Predicted)
• Appearance: /
• Density: 0.984
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.51±0.46(Predicted)
• CAS DataBase Reference: Carbamic acid, [(2S)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(2S)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)(121103-15-9)
• EPA Substance Registry System: Carbamic acid, [(2S)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)(121103-15-9)

Safety Data

• Hazardous Substances Data: 121103-15-9(Hazardous Substances Data)

Usage

General Description

Carbamic acid, [(2S)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI) is a chemical compound with the molecular formula C7H16N2O2. It is an ester derivative of carbamic acid, and contains an amino group and a tert-butyl group. Carbamic acid, [(2S)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI) is used in the pharmaceutical industry as a reagent in the synthesis of various drugs and biologically active molecules. It is also known for its potential use as a precursor in the preparation of organic compounds. The chemical properties and potential applications of Carbamic acid, [(2S)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI) make it an important and versatile compound in chemical research and development.

Upstream product

• 15967-72-3 (S)-1,2-diaminopropane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 400652-51-9 C₁₆H₂₄N₂O₄ 
• 19777-66-3 (S)-propane-1,2-diamine dihydrochloride 
• 1299490-85-9 (S)-1-(tert-butoxycarbonyl)-4-methyl-2-phenylimidazoline 
• 1299491-18-1 N-(tert-butoxycarbonyl)-4-methyl-2-phenylimidazole 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 919110-10-4 ((S)-2-(2-chloroacetyl)-(4-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-benzylamino)-propyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists

The synthesis, SAR, and preclinical characterization of a series of substituted 6,7-dihydro[1,2,4]triazolo[4,3]pyrazin-8(5H)-one P2X7 receptor antagonists are described. Optimized leads from this series comprise some of the most potent human P2X7R antagonists reported to date (IC50s 50 = 0.8 mg/kg).

P2X7 MODULATORS

The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

Parallel synthesis of an oligomeric imidazole-4, 5-dicarboxamide library

A library of oligomeric compounds was synthesized based on the imidazole-4, 5-dicarboxylic acid scaffold along with amino acid esters and chiral diamines derived from amino acids. The final compounds incorporate nonpolar amino acids (Leu, Phe, Trp), polar amino acids (Ser, Asp, Arg), and neutral amino acids (Gly, Ala), and were designed to be useful in screening for inhibitors of protein-protein interactions. Many of the protected and deprotected oligomers show evidence of conformational isomers persistent at room temperature in aqueous solution. A total of 317 final oligomers, out of 441 targeted compounds, were obtained in high analytical purity and of sufficient quantity to submit them for high-throughput screening as part of the NIH Roadmap.